About Stijn van den Borne, MSc
MSc in Biomedical Sciences | Pharmaceutical R&D | Medical Affairs | Medical Writer | Medical Editor | Oncology
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US FDA approved immune-checkpoint inhibitors updated 08-Dec-2020
8th December 2020 /19 Comments/in AE Management, Gastrointestinal Cancer, Genitourinary Cancer, Gynaecological Cancer, Haematology, Head and Neck Cancer, ImmunoOncology, Immunotherapy, irAE Management, Lung Cancer, Melanoma & Skin Cancer, Oncology /by Stijn van den Borne, MScKnow all the United States Food and Drug Administration (U.S. FDA) approved immune-checkpoint inhibitors. Members of MediPaper can download the free PPT slides summarising the U.S. FDA approved immune-checkpoint inhibitors and other U.S. FDA approved immunotherapies.
Nestlé Health Sciences
16th April 2020 /Enter your password to view comments./in - /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
更新: Covid-19患者的臨床特徵
26th February 2020 /0 Comments/in COVID-19, Critical Care Medicine, Infectious Disease, Internal Medicine, Pneumonia, SARS-CoV2 /by Stijn van den Borne, MScDr Siddharth綜合了21個病例報告,並分析了目前1689名Covid-19肺炎患者的臨床特徵,以及2198名患者的人口統計學數據。
Updated: Clinical characteristics of patients with COVID-19
26th February 2020 /1 Comment/in COVID-19, Critical Care Medicine, Infectious Disease, Internal Medicine, Pneumonia, SARS-CoV2 /by Stijn van den Borne, MScDr Siddharth analysed the clinical characteristics of 1,689 #COVID19 patients from 21 publications, and the demographics of 2,198 2019nCoV patients.
開始? 結束?
22nd February 2020 /1 Comment/in COVID-19, Critical Care Medicine, Infectious Disease, Internal Medicine, Pneumonia, SARS-CoV2 /by Stijn van den Borne, MSc香港的 Covid19 病例每天增加,不免令人恐懼。然而,更具參考價值的分析是「流行病曲線」,它著重這些病例的症狀發作日期,而不是病例發現的日期。
COVID-19 in Hong Kong: the end of the beginning?
22nd February 2020 /1 Comment/in COVID-19, Critical Care Medicine, Infectious Disease, Internal Medicine, Pneumonia, SARS-CoV2 /by Stijn van den Borne, MScWatching the daily increase in Covid-19 cases in Hong Kong is scary. However, a more useful analysis is the ‘epidemic curve’, which looks at the date of symptom onset of cases rather than the date of case detection.
How do people get COVID-19 in Hong Kong
20th February 2020 /0 Comments/in COVID-19, Critical Care Medicine, Infectious Disease, Internal Medicine, Pneumonia, SARS-CoV2 /by Stijn van den Borne, MScDr Siddharth Sridhar, Specialist in Clinical Microbiology & Infection, looked at the main settings of Covid-19 transmission in Hong Kong (as of 20/2/2020)
在本港,人們如何感染Covid-19?
20th February 2020 /1 Comment/in COVID-19, Critical Care Medicine, Infectious Disease, Internal Medicine, Pneumonia, SARS-CoV2 /by Stijn van den Borne, MSc臨床微生物學及傳染病學專科醫生 Dr Siddharth Sridhar分析了香港Covid-19傳播的主要情況(截至2020年2月20日)
2019-nCoV – Summary of the situation in HK as of Feb 6, 2020
7th February 2020 /1 Comment/in COVID-19, Critical Care Medicine, Infectious Disease, Internal Medicine, Pneumonia, SARS-CoV2 /by Stijn van den Borne, MScDr Siddharth Sridhar provides a brief overview on the infections with 2019-nCoV in Hong Kong as of Feb 6, 2020. Are they imported cases, local transmissions? And if locally transmitted how closely are the patients related?
2019-nCoV在本港的概況(截至2020年2月6日)
7th February 2020 /1 Comment/in COVID-19, Critical Care Medicine, Infectious Disease, Internal Medicine, Pneumonia, SARS-CoV2 /by Stijn van den Borne, MScDr Siddharth Sridhar簡述了本港2019-nCoV病毒截至2020年2月6日的概況。這些感染個案是外來病例,還是本地傳播? 如果是本地傳播,患者之間的關係有多緊密?
新型冠狀病毒(2019-nCoV)的傳染性有多高?
4th February 2020 /1 Comment/in COVID-19, Critical Care Medicine, Infectious Disease, Internal Medicine, Pneumonia, SARS-CoV2 /by Stijn van den Borne, MScDr Siddharth Sridhar分析了2019-nCoV的基本繁殖數量-一種衡量病原體的「傳染性」,以及它可能在社區中傳播的程度,並將其與早期階段的SARS和麻疹爆發進行比較。
How infectious is novel coronavirus (2019-nCoV)
3rd February 2020 /1 Comment/in COVID-19, Critical Care Medicine, Infectious Disease, Internal Medicine, Pneumonia, SARS-CoV2 /by Stijn van den Borne, MScDr Siddharth Sridhar describes the basic reproduction number – a measure of how ‘infectious’ a pathogen is and how likely it is to spread through a community – for 2019-nCoV, and compares this with the early phases of the SARS and measles outbreaks.
2019-nCoV: how stable are coronaviruses in the environment?
2nd February 2020 /1 Comment/in COVID-19, Critical Care Medicine, Infectious Disease, Internal Medicine, Pneumonia, SARS-CoV2 /by Stijn van den Borne, MScDr Siddharth Sridhar, looked at how stable coronaviruses are on a variety of environmental surfaces, and provides recommendations to prevent infection with 2019-nCoV.
2019-nCoV: 冠狀病毒在環境中的穩定性
2nd February 2020 /2 Comments/in COVID-19, Critical Care Medicine, Infectious Disease, Internal Medicine, Pneumonia, SARS-CoV2 /by Stijn van den Borne, MScDr Siddharth Sridhar研究了冠狀病毒在各種環境表面上的穩定性,並提供了預防2019-nCoV感染的建議。
Who gets severe novel coronavirus (2019-nCoV) infection?
1st February 2020 /0 Comments/in COVID-19, Critical Care Medicine, Infectious Disease, Internal Medicine, Pneumonia, SARS-CoV2 /by Stijn van den Borne, MScHere, I examined the data of 28 patients from 5 publications who had severe pneumonia due to 2019-nCoV requiring ICU admission and/or resulting in death.
誰受到 2019-nCoV嚴重感染?
1st February 2020 /1 Comment/in COVID-19, Critical Care Medicine, Infectious Disease, Internal Medicine, Pneumonia, SARS-CoV2 /by Stijn van den Borne, MSc綜合5篇醫學文獻中28名2019-nCoV肺炎患者的數據,這 28名患者因2019-nCoV肺炎而需要接受深切治療及/或死亡。與許多呼吸道病毒一樣,長者受的影響較大;特色是男性患者較多及幾乎沒有嚴重的兒科病例,但有待進一步確認。
Highlights of the 8th Asia Pacific Symposium on Cerebrovascular Disease
16th December 2019 /Enter your password to view comments./in Cardiovascular, Neurology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
ASCO 2019 Lung Cancer: 36 Oral Presentations of the ASCO19 lung cancer track summarised
12th June 2019 /0 Comments/in ASCO 2019 Annual Meeting, Chemotherapy, Conferences, Immunotherapy, Lung Cancer, Oncology, Radiology, Surgery, Targeted Therapies, Translational Research /by Stijn van den Borne, MScNon-small cell lung cancer (NSCLC) was a key feature of the American Society of Clinical Oncology (ASCO) 2019 annual meeting. This year, exciting results with neoadjuvant immunotherapy (I-O) from the LCMC3, NEOSTAR, and GECP16/03_NADIM studies as well as combinations of I-O and PARP-inhibitors with chemoradiation therapy, and more. A summary of 36 oral presentations on NSCLC, SCLC, and Mesothelioma.
ASCO 2019 Breast Cancer: The ASCO19 breast cancer track summarised
3rd June 2019 /0 Comments/in ASCO 2019 Annual Meeting, Breast Cancer, Chemotherapy, Conferences, Immunotherapy, Oncology, Targeted Therapies, Translational Research /by Stijn van den Borne, MScBreast cancer: a front-runner when it comes to the development of novel therapeutic strategies. With the advent of newer targeted- and immunotherapies, oncologists have an increment of options to offer their patients. The American Society of Clinical Oncology’s (ASCO) 2019 Breast Cancer track offered an extensive look at the latest advancements and updates from on-going trials covering the various subtypes of breast cancer.
FDA approves avelumab plus axitinib for renal cell carcinoma
14th May 2019 /0 Comments/in Genitourinary Cancer, ImmunoOncology, Immunotherapy, US FDA Onc\Haem Approvals /by Stijn van den Borne, MScOn 14 May 2019, the FDA approved the combination of avelumab (Bavencio®, Merck KGaA/Pfizer) plus axitinib (Inlyta®, Pfizer) for the first-line treatment of advanced renal cell carcinoma (RCC) patients.
Can a novel, temporary, and fully resorbable surgical implant improve the outcome of common hockey and soccer injuries?
26th April 2019 /0 Comments/in Hernia Repair, Internal Medicine, Medical News Asia, News, Surgery /by Stijn van den Borne, MScUPPSALA, Sweden, April 24, 2019 /PRNewswire/ — Researchers of the Erasmus University Medical Center in Rotterdam − the Netherlands, consider that the synthetic and fully resorbable TIGR® Matrix surgical mesh (Novus Scientific AB, Uppsala − Sweden) may reduce frequent risks related to the surgical repair of Sportsman’s hernia.
KEYNOTE-158: pembrolizumab in previously treated advanced cervical cancer
24th April 2019 /0 Comments/in Chemotherapy, Gynaecological Cancer, Haematology, ImmunoOncology, Immunotherapy, Oncology /by Stijn van den Borne, MScImmunotherapy with programmed death 1 (PD-1) antibody pembrolizumab led to an objective response rate (ORR) of 14.6% in previously treated advanced cervical cancer patients with PD-L1–positive disease, as reported by Chung et al. on behalf of the KEYNOTE-158 investigators in the Journal of Clinical Oncology.
Atezolizumab +/- cobimetinib vs regorafenib for previously treated metastatic colorectal cancer (IMblaze370)
22nd April 2019 /0 Comments/in Gastrointestinal Cancer, ImmunoOncology, Immunotherapy, Oncology, Targeted Therapies /by Stijn van den Borne, MScCombining programmed death 1 ligand (PD-L1) inhibitor atezolizumab with MEK-inhibitor cobimetinib in patients with previously treated metastatic colorectal cancer (mCRC) does not improve the overall survival (OS) when compared to regorafenib, as was reported by the investigators of the IMblaze370 (NCT02788279) trial in the Lancet Oncology.
Case sharing – use of avelumab in Merkel cell carcinoma
8th March 2019 /Enter your password to view comments./in ImmunoOncology, Immunotherapy, Melanoma & Skin Cancer, Oncology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
Combinations: upcoming treatment strategies in metastatic renal cell carcinoma
5th March 2019 /Enter your password to view comments./in -, Genitourinary Cancer, ImmunoOncology, Immunotherapy, Oncology, Translational Research /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
Erasmus University MC investigating a new surgical matrix to reduce post-operative complications
16th January 2019 /0 Comments/in Medical News Asia, Oncology, Surgery /by Stijn van den Borne, MScThe synthetic and fully resorbable TIGR®Matrix surgical mesh (Novus Scientific AB, Uppsala − Sweden) might be an interesting candidate for the prevention of complications frequently observed with permanent mesh placement, according to Professor Johan Lange of the Erasmus University in Rotterdam − the Netherlands.
Keytruda® FDA approved for recurrent and metastatic Merkel cell carcinoma
14th January 2019 /0 Comments/in ImmunoOncology, Immunotherapy, Melanoma & Skin Cancer, Oncology, US FDA Onc\Haem Approvals /by Stijn van den Borne, MScOn 19 December 2018, pembrolizumab (Keytruda®, Merck) received accelerated approval by the FDA for the treatment of recurrent locally advanced or metastatic (R/M) Merkel cell carcinoma (MCC) in adult and paediatric patients.
DECLARE-TIMI 58 – Imagine 1
11th January 2019 /Enter your password to view comments./in - /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
Steven E Lipshultz – Who Needs Cardioprotection
19th December 2018 /Enter your password to view comments./in - /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
I-O in Special Populations: Chronic Viral Hepatitis Carriers
18th November 2018 /Enter your password to view comments./in Anaesthesiology, Cardiovascular, ERAS, TIVA /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
ESMO 2018 HCC: The ESMO18 hepatobiliary cancer track summarised
3rd November 2018 /1 Comment/in Conferences, ESMO 2018 Annual Meeting, Gastrointestinal Cancer, ImmunoOncology, Immunotherapy, Oncology, Targeted Therapies, Translational Research /by Stijn van den Borne, MScWhereas this year’s American Society of Clinical Oncology Annual Meeting (ASCO 2018) boasted two Phase III studies and four Phase II studies with notable results in hepatocellular carcinoma (HCC), the trend did not continue to the European Society for Medical Oncology Conference (ESMO 2018), held in Münich, Germany between October 19-23, 2018. The focus for this years ESMO was mostly on biliary-tract cancers (BTC). Welcome to the hepatobiliary track of ESMO 2018.
Management of Immune-Mediated Hepatitis: a Case Report
31st October 2018 /Enter your password to view comments./in China, Genitourinary Cancer, ImmunoOncology, Immunotherapy, irAE Management, Oncology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
Early treatment with ocrelizumab lowers 5-year brain atrophy rates in MS
25th October 2018 /0 Comments/in ECTRIMS 2018, Neurology /by Stijn van den Borne, MScRelapsing multiple sclerosis (MS) patients initiating ocrelizumab (Ocrevus®, Roche/Genentech) two years earlier had significant reductions in 5-year brain atrophy rates when compared to those switching from interferon β-1a, as reported in the latest results from the OPERA studies’ extension phase.
ESMO 2018 NSCLC: The ESMO18 non-small cell lung cancer track summarised
17th October 2018 /Enter your password to view comments./in - /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
First-line osimertinib vs EGFR-TKI in Asian patients with advanced NSCLC
24th September 2018 /0 Comments/in Lung Cancer, Oncology, Targeted Therapies /by Stijn van den Borne, MScFirst-line osimertinib was associated with a clinically meaningful progression-free survival (PFS) improvement when compared to a standard-of-care (SOC) epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in a sub-analysis of Asian patients who participated in the FLAURA trial (NCT02296125).
ImmunoOncology: Dr Oscar Chan on the treatment of irAE rash
21st September 2018 /Enter your password to view comments./in ImmunoOncology, Immunotherapy, irAE Management, Oncology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
Prof Stefan Kasper on I-O in EXTREME-ineligible SCCHN
19th September 2018 /Enter your password to view comments./in Head and Neck Cancer, ImmunoOncology, Immunotherapy, irAE Management, Oncology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
I-O in Special Populations: the Treatment of Immunotherapy-Induced Pneumonitis
14th September 2018 /Enter your password to view comments./in ImmunoOncology, Immunotherapy, irAE Management, Oncology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
ASCO18 NSCLC PPT Download
25th June 2018 /Enter your password to view comments./in - /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
ASCO18 BC PPT Download
19th June 2018 /Enter your password to view comments./in - /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
ASCO 2018 Breast Cancer: The ASCO18 breast cancer track summarised
19th June 2018 /2 Comments/in ASCO 2018 Annual Meeting, Breast Cancer, Chemotherapy, Conferences, Immunotherapy, Oncology, Targeted Therapies, Translational Research /by Stijn van den Borne, MScBreast cancer: a front-runner when it comes to the development of novel therapeutic strategies. With the advent of newer targeted- and immunotherapies, oncologists have an increment of options to offer their patients. The American Society of Clinical Oncology’s (ASCO) 2018 Breast Cancer track offered an extensive look at the latest advancements and updates from on-going trials covering the various subtypes of breast cancer.
ASCO18 HCC PPT Download
12th June 2018 /Enter your password to view comments./in - /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
Showcase
29th May 2018 /Enter your password to view comments./in - /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
FDA safety alert: use of immunotherapy in metastatic urothelial cancer with low PD-L1 expression
18th May 2018 /2 Comments/in US FDA Onc\Haem Approvals /by Stijn van den Borne, MScOn May 18, the United States (US) Food and Drug Administration (FDA) issued an alert about the decreased survival in studies with pembrolizumab (Keytruda®) and atezolizumab (Tecentriq®) as single agent first-line therapy for patients with metastatic urothelial cancer (mUCC) and low expression of the programmed death ligand 1 (PD-L1) protein.
AACR 2018: first-line atezolizumab, bevacizumab plus chemotherapy active in non-squamous NSCLC
10th May 2018 /4 Comments/in Chemotherapy, ImmunoOncology, Immunotherapy, Lung Cancer, Oncology, Translational Research /by Stijn van den Borne, MScFirst-line atezolizumab plus bevacizumab, carboplatin and paclitaxel improves PFS in patients with non-squamous NSCLC. Two presentations on the IMPower150 study by Martin Reck (ELCC 2018) and Mark Socinski (AACR 2018) discussed the frontline addition of atezolizumab to bevacizumab and chemotherapy in different lung cancer subgroups (NCT02366143).
FDA approves daratumumab plus VMP for transplant ineligible myeloma patients
7th May 2018 /1 Comment/in US FDA Onc\Haem Approvals /by Stijn van den Borne, MScOn 7 May 2018 the US FDA approved daratumumab (DARZALEX®) in combination with the VMP regimen (bortezomib (VELCADE®), melphalan, and prednisone) for the treatment of patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant (ASCT).
US FDA approved CAR-T cell and BiTE immunotherapy – Updated 2-May-2018
2nd May 2018 /5 Comments/in Haematology, ImmunoOncology, Immunotherapy, Oncology /by Stijn van den Borne, MScThe two CAR-T cell immunotherapies axicabtagene ciloleucel (Yescarta®) and tisagenlecleucel (Kymriah®) and the BiTE blinatumomab (Blincyto®) have in common that they target CD19 on the cancer cells. Do you know all the US FDA approved CAR-T and BiTE immunotherapies?
Nivolumab-Ipilimumab Combination: A New Option for TMB-High NSCLC (CheckMate 227)
21st April 2018 /6 Comments/in Chemotherapy, ImmunoOncology, Immunotherapy, Lung Cancer, Oncology, Translational Research /by Stijn van den Borne, MScAACR 2018: First-line nivolumab-ipilimumab in TMB-high NSCLC with was associated with a more than tripled 1-year progression-free survival (PFS) rate compared to platinum-based chemotherapy in the Phase III CheckMate 227 trial (NCT02477826).
Frontline Combination of Pembrolizumab and Chemotherapy: A New Standard of Care for Non-squamous NSCLC
19th April 2018 /4 Comments/in Chemotherapy, ImmunoOncology, Immunotherapy, Lung Cancer, Oncology, Translational Research /by Stijn van den Borne, MScAACR 2018: Frontline pembrolizumab plus chemotherapy in NSCLC reduces the risk of death by more than 50%. The Phase III KEYNOTE-189 trial combined pembrolizumab (Keytruda®) plus standard of care platinum-based chemotherapy in non-squamous non–small cell lung cancer (NSCLC) without EGFR or ALK genetic aberrations (NCT0278680)
Pembrolizumab effective in frontline NSCLC with low PD-L1 expression
10th April 2018 /1 Comment/in Chemotherapy, ImmunoOncology, Immunotherapy, Lung Cancer, Oncology, Translational Research /by Stijn van den Borne, MScPembrolizumab (Keytruda®) as single-agent immunotherapy in the frontline setting of any histology NSCLC with a PD-L1 expression ≥1% was associated with improved overall survival (OS) when compared to platinum-doublet chemotherapy in the KEYNOTE-042.
I-O in Special Populations: Diabetes and Concomitant Steroids
6th April 2018 /Enter your password to view comments./in AE Management, ImmunoOncology, Immunotherapy, irAE Management, Oncology, Radiology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
Crizotinib beneficial for East-Asian NSCLC patients with ROS1 alterations
4th April 2018 /1 Comment/in China, Lung Cancer, Oncology, Targeted Therapies /by Stijn van den Borne, MScCrizotinib in Asian NSCLC patients with ROS1 alterations was associated with a 71.7% objective response rate (ORR) with a median duration of response (DOR) of 19.7 months (95% CI, 14.1 months – not reached). Learn more about the results with crizotinib in East-Asian non-small cell lung cancer (NSCLC) patients harbouring c-ros oncogene 1 (ROS1) rearrangements.
Nivolumab for NPC: immunotherapy active in nasopharyngeal carcinoma (NCI-9742)
31st March 2018 /0 Comments/in Head and Neck Cancer, ImmunoOncology, Immunotherapy, Oncology /by Stijn van den Borne, MScNivolumab (OpdivoⓇ) immunotherapy is active in nasopharyngeal carcinoma (NPC). A study published in JCO by Brigette Ma (CUHK) and a team of researchers from Hong Kong, Singapore, and the US showed promising results with nivolumab in NPC. Read more about immunotherapy in NPC.
Making sense of 1st-line immunotherapy in non-small cell lung cancer (NSCLC) | Members
27th March 2018 /0 Comments/in - /by Stijn van den Borne, MScThe expansion of therapeutic options with immunotherapies will reflect a dramatic change in the guidelines for lung cancer, where immunotherapies mostly compete with the use of chemotherapeutic agents. A brief communication on immunotherapies for NSCLC.
Immunotherapies for NSCLC PowerPoint™ – Download
26th March 2018 /1 Comment/in - /by Stijn van den Borne, MScMaking sense of 1st-line immunotherapy in non-small cell lung cancer (NSCLC)
26th March 2018 /5 Comments/in Guidelines, ImmunoOncology, Immunotherapy, Lung Cancer, Oncology /by Stijn van den Borne, MScThe expansion of therapeutic options with immunotherapies will reflect a dramatic change in the guidelines for lung cancer, where immunotherapies mostly compete with the use of chemotherapeutic agents. A brief communication on immunotherapies for NSCLC.
Which drugs are immunotherapies?
23rd March 2018 /0 Comments/in - /by Stijn van den Borne, MScWhich drugs do you consider to be immunotherapies? Take our two-minute poll now.
Achieving Long-Term Survival in the First-Line Treatment of Metastatic Renal Cell Carcinoma; A Balancing Act of Efficacy and Side-Effects
8th January 2018 /Enter your password to view comments./in - /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
Achieving Long-Term Survival in the First-Line Treatment of Metastatic Renal Cell Carcinoma; A Balancing Act of Efficacy and Side-Effects
8th January 2018 /Enter your password to view comments./in - /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
Achieving Long-Term Survival in the First-Line Treatment of Metastatic Renal Cell Carcinoma; A Balancing Act of Efficacy and Side-Effects
29th November 2017 /Enter your password to view comments./in Genitourinary Cancer, Oncology, Surgery /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
TIVA: enhanced recovery by optimized anesthetics 2
24th November 2017 /Enter your password to view comments./in - /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
TIVA: enhanced recovery by optimized anesthetics 1
24th November 2017 /Enter your password to view comments./in - /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
TIVA: enhanced recovery by optimized anesthetics
23rd November 2017 /Enter your password to view comments./in Anaesthesiology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
Do you know your lifetime risk on Pancreatic Cancer?
20th November 2017 /0 Comments/in Gastrointestinal Cancer, Oncology /by Stijn van den Borne, MScNovember turns purple for pancreatic cancer awareness. Focus is on one of the most difficult-to-treat tumours with the final objective: to double the survival of pancreatic cancer by 2020. What is your risk to develop pancreatic cancer? And how likely are you to get cured of the disease?
CSA2017: Prof Huang Yuguang on the use of ERAS and TIVA in China
7th November 2017 /Enter your password to view comments./in Anaesthesiology, China /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
CSA2017: Prof Xiong Lize on the status of ERAS in China
7th November 2017 /Enter your password to view comments./in Anaesthesiology, China /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
Luminal Breast Cancer: can CDK4/6 Inhibition by Palbociclib Improve on Chemotherapy?
25th October 2017 /1 Comment/in Breast Cancer, Endocrine Therapy, Oncology /by Stijn van den Borne, MScCan chemotherapy be avoided in women with hormone-sensitive breast cancer? This is a prominent question in the treatment of breast cancer around the globe.
Pembrolizumab approved for advanced gastric cancer
22nd September 2017 /0 Comments/in Chemotherapy, Gastrointestinal Cancer, ImmunoOncology, Immunotherapy, Translational Research, US FDA Onc\Haem Approvals /by Stijn van den Borne, MScOn September 22, 2017, the FDA granted accelerated approval to pembrolizumab (KEYTRUDA, Merck) for use in patients with locally advanced or metastatic, gastric or gastroesophageal junction (GEJ) adenocarcinoma positive for PD-L1 as determined by an FDA-approved companion diagnostic (CDx) and progressing after ≥2 prior systemic therapies, including a fluoropyrimidine- and platinum-containing regimen, and, when appropriate, HER2-targeted therapy.
Nivolumab approved for sorafenib-refractory HCC
22nd September 2017 in Gastrointestinal Cancer, ImmunoOncology, Immunotherapy, Targeted Therapies, US FDA Onc\Haem Approvals /by Stijn van den Borne, MScOn September 22, 2017, the Food and Drug Administration granted accelerated approval to nivolumab (OPDIVO, Bristol-Myers Squibb Co.) for the treatment of hepatocellular carcinoma (HCC) in patients who have been previously treated with sorafenib. Approval was based on a 154-patient subgroup of CHECKMATE-040 (NCT 01658878), a multicenter, open-label trial conducted in patients with HCC and […]
Nivolumab for Renal Carcinoma: Getting the Most Out of PD-1 Immunotherapy
19th September 2017 /Enter your password to view comments./in AE Management, Genitourinary Cancer, Head and Neck Cancer, ImmunoOncology, Immunotherapy, irAE Management, Oncology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
25th Annual Meeting of the Chinese Society of Anaesthesiology
6th September 2017 /1 Comment/in Anaesthesiology, China, Conferences /by Stijn van den Borne, MScAlmost 10,000 doctors from China joining together to learn about the latest developments in anaesthesiology. Impressions of the 25th Annual Meeting of the Chinese Society of Anaesthesiology – CSA2017 – 中华医学会第25 次全国麻醉学术年会
Latest global trends of health measure and impact on survival rate
16th August 2017 /0 Comments/in /by Stijn van den Borne, MScLack of strength and diabetes are becoming epidemic in the ageing population, and patients often ignore early signs and are unaware how to prevent these problems.
Pharma Digital Marketing: Lackluster or Blockbuster?
7th August 2017 /0 Comments/in - /by Stijn van den Borne, MScPharmaceutical companies are not delivering the online content physicians consider supportive in better patient management. This was concluded by a survey among 2,784 U.S. physicians across 25+ different specialities. Only 27% agreed that pharma websites are a credible source of information.
Should all Women with Endocrine-Sensitive and Operable Breast Cancer Receive Adjuvant Hormonal Therapy?
5th July 2017 /0 Comments/in Breast Cancer, Endocrine Therapy, Oncology /by Stijn van den Borne, MScOne in six women with early, operable breast cancer may not need years of adjuvant hormonal therapy after primary treatment. This was the conclusion of a recent study published in JAMA (the Journal of the American Medical Association) Oncology.
Interested in Attending an Immunooncology Conference?
21st June 2017 /0 Comments/in Conferences, ImmunoOncology, Oncology, Translational Research /by Stijn van den Borne, MScThe CICS Annual Conference on Immuno Oncology is offering the most significant advances in the world of oncology. The goal of the meeting is to convey the clinical and translational advances in various areas of cancer immunology to medical oncologists, medical students, and other health professionals.
AMNOG: Germany Pharmaceuticals Pricing Legislation Overview
15th December 2016 /0 Comments/in Pricing & Cost Effectiveness /by Stijn van den Borne, MScGermany has introduced a new price-evaluation system for pharmaceuticals in 2011. How does this system work? And has the implementations been a successful one? An overview of the efficacy-measures of the AMNOG.
Interested in Attending an Immuno-Oncology Conference?
10th November 2016 /0 Comments/in - /by Stijn van den Borne, MScCIIO is an Annual Conference offering the most significant advances in the world of oncology. The goal of the meeting is to convey the clinical and translational advances in various areas of cancer immunology to medical oncologists, medical students, and other health professionals.
ESMO16 Breast Cancer: Palbociclib, Ribociclib and Abemaciclib Data
9th November 2016 /2 Comments/in Breast Cancer, Conferences, Endocrine Therapy, Oncology /by Stijn van den Borne, MScCyclin-dependent Kinase 4 and 6 (CDK4/6) inhibitors have shown clinical activity in patients with endocrine-resistant metastatic breast cancer. During the European Society for Medical Oncology (ESMO) Annual Meeting 2016, significant updates on studies with CDK4/6 inhibitors ribociclib, palbociclib and abemaciclib were presented.
PD-L1 Biomarker: a Comparison of ASCO2016 PD-1 and PD-L1 Data
26th October 2016 /Enter your password to view comments./in Gastrointestinal Cancer, Genitourinary Cancer, Haematology, Head and Neck Cancer, ImmunoOncology, Lung Cancer, Melanoma & Skin Cancer, Pathology, Translational Research /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
Novel Biomarker for Ipilimumab Treatment may aid Future Patient Selection in Several Malignancies
24th October 2016 /4 Comments/in ImmunoOncology, Oncology, Pathology, Translational Research /by Stijn van den Borne, MScThe number of different types of T-helper cells (Th) and cytotoxic T cells (CD8) may predict response to ipilimumab in several malignancies. This was concluded by Dr Juan Pablo Márquez Manríquez who presented the study at the ESMO conference on behalf of the investigators of the Sonora Cancer Research Center (CICS) in Mexico and the United States (U.S.).
ESMO16 Ipilimumab data – Download the PPT
11th October 2016 /Enter your password to view comments./in Conferences, ImmunoOncology, Melanoma & Skin Cancer, Oncology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
ESMO16 Pembrolizumab data – Download the PPT
10th October 2016 /Enter your password to view comments./in Conferences, Head and Neck Cancer, ImmunoOncology, Lung Cancer, Melanoma & Skin Cancer, Oncology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
ESMO16 Durvalumab, Avelumab, Tremelimumab Data – Download the PPT
10th October 2016 /Enter your password to view comments./in Conferences, Gastrointestinal Cancer, Genitourinary Cancer, ImmunoOncology, Lung Cancer, Oncology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
ESMO16 Atezolizumab data – Download the PPT
9th October 2016 /Enter your password to view comments./in Conferences, Genitourinary Cancer, ImmunoOncology, Oncology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
ESMO16 Nivolumab data – Download the PPT
9th October 2016 /Enter your password to view comments./in Conferences, Genitourinary Cancer, Haematology, ImmunoOncology, Melanoma & Skin Cancer, Oncology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
Cancer symptom awareness linked to survival
30th September 2016 /2 Comments/in Gynaecological Cancer, Oncology /by Stijn van den Borne, MScIncreased cancer awareness improves survival, according to a recent study by Cancer Research UK (CRUK) published in the British Journal of Cancer (BJC). The researchers matched cancer symptom awareness from a population-based survey in over 35,000 people across the UK with the cancer registry.
ASCO Guideline NeoAdjuvant Chemotherapy for Ovarian Cancer Updated
27th September 2016 /0 Comments/in Breast Cancer, Gynaecological Cancer, Oncology /by Stijn van den Borne, MScIn women with stage IIIC or IV ovarian cancer, primary cytoreductive surgery (PCS) may be preferred when there is a high chance to achieve cytoreduction to <1 cm with acceptable morbidity. This was concluded by an expert panel who published clinical guidelines in the Journal of Clinical Oncology (JCO) this week.
IMM101 plus Gemcitabine Hopeful in Metastatic Pancreatic Cancer
25th September 2016 /3 Comments/in Gastrointestinal Cancer, ImmunoOncology, Oncology /by Stijn van den Borne, MScA phase II proof-of-concept (POC) study investigating the safety and tolerability of immune modulator IMM-101 plus gemcitabine vs. single agent gemcitabine in advanced pancreatic ductal adenocarcinoma (PDAC) showed significant improved progression-free survival (PFS) and overall survival (OS) in metastatic patients receiving the combination treatment.
Palbociclib (Ibrance®): First in Class CDK4/6 Inhibitor
17th September 2016 /3 Comments/in Breast Cancer, Oncology, Targeted Therapies /by Stijn van den Borne, MScAt the American Association for Cancer Research, 2014 annual meeting (AACR) Richard Finn presented the results of the PALOMA-1 study with Ibrance® (palbociclib), an oral inhibitor of cyclin-dependent kinase 4/6 (CDK4/6). Based on the results of this Phase 2 study, palbociclib was recently approved by the United States Drug and Food Administration (U.S. FDA). What is the current level of evidence on palbociclib in approved indications?
Ki67 in Breast Cancer: an overview
6th September 2016 /4 Comments/in Breast Cancer, Oncology, Pathology, Surgery, Targeted Therapies, Translational Research /by Stijn van den Borne, MScRecent studies have shown new possible applications for Ki67. Huh et al. showed that low Ki67 levels in healthy breast tissue correlated with a lesser lifetime chance of breast cancer. Another study by Arnedos and colleagues concluded that palbociclib was able to invoke a significant Ki67-level drop. After a decade of Ki67-controversies, these results put the marker back in the spotlight.
Medical Blog SEO Optimisation
2nd August 2016 /1 Comment/in - /by Stijn van den Borne, MScPatient groups, pharmaceutical companies, scientific and medical blogs. They all have one thing in common, they offer content to patients and doctors on diseases and possible treatments. Over the recent years, such blogs have become plenty but a few. How to get noticed by your targeted audience?
ASCO16 Ribociclib & Abemaciclib Data
5th June 2016 /Enter your password to view comments./in Breast Cancer, Oncology, Targeted Therapies /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
ASCO16 palbociclib (Ibrance©) Data
4th June 2016 /Enter your password to view comments./in Breast Cancer, Gynaecological Cancer, Oncology, Targeted Therapies /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
ASCO16 Avelumab, Durvalumab, and Tremelimumab
3rd June 2016 /Enter your password to view comments./in Genitourinary Cancer, ImmunoOncology, Immunotherapy, Lung Cancer, Melanoma & Skin Cancer, Oncology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
ASCO16 Atezolizumab (Tecentriq©) Data
2nd June 2016 /Enter your password to view comments./in Genitourinary Cancer, ImmunoOncology, Immunotherapy, Lung Cancer, Oncology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
ASCO16 Ipilimumab (Yervoy©) Data
31st May 2016 /Enter your password to view comments./in ImmunoOncology, Immunotherapy, Melanoma & Skin Cancer, Oncology /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.
ASCO16 Nivolumab (Opdivo©) Data
29th May 2016 /Enter your password to view comments./in Cardiovascular, ImmunoOncology, Immunotherapy, Lung Cancer, Melanoma & Skin Cancer /by Stijn van den Borne, MScThere is no excerpt because this is a protected post.