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CARDIOVASCULAR DISEASE

Cabotegravir and rilpivirine intramuscular combination safe in women

Medical writer: Kirsty LEE | Last updated: 11 December 2020 | In: Gastrointestinal Cancer, Lung Cancer, Oncology, Targeted Therapies

Article Keywords

NSCLC, CRC, KRAS, AMG 510, KRAS G12C, RAS, solid tumours, sotorasib

Women account for a disproportionate percentage of new human immunodeficiency virus (HIV) infections in sub-Saharan Africa, comprising 59% of 18 million new adult HIV infections in 2017.1Nachman S et al. Lancet HIV. 2019;6(8):e552-e558. Current treatment for HIV patients consists of daily oral antiretroviral therapy (ART), but inadequate or incomplete adherence leads to treatment failure and drug resistance.1Nachman S et al. Lancet HIV. 2019;6(8):e552-e558. One option to improve adherence is long-acting ART, which would be given on a monthly or bimonthly basis.1Nachman S et al. Lancet HIV. 2019;6(8):e552-e558.

Cabotegravir (CAB) is a potent integrase strand transfer inhibitor (INSTI) with unique pharmacokinetic properties that allow for delivery as a long-acting nanosuspension for monthly to quarterly intramuscular (IM) injections.2Trezza C et al. Curr Opin HIV AIDS. 2015;10(4):239-245. It is currently under investigation in combination with rilpivirine (RPV) for the treatment of HIV.2Trezza C et al. Curr Opin HIV AIDS. 2015;10(4):239-245. At the HIV Glasgow 2020 conference, the results for the subgroup of women in the ATLAS-2M trial were presented.3Benn P et al. Abstract P017. Presented at HIV Glasgow 2020.

The open-label phase 3 non-inferiority ATLAS-2M trial investigated CAB+RPV maintenance therapy administered every 8 weeks (Q8W; CAB 600mg + RPV 900mg) or Q4W (CAB 400mg + RPV 600mg) in treatment-experienced, HIV-infected adults.3Benn P et al. Abstract P017. Presented at HIV Glasgow 2020. A subgroup analysis by sex at birth was planned, and the trial had a target recruitment for women of 25%.3Benn P et al. Abstract P017. Presented at HIV Glasgow 2020. The primary endpoint was the proportion of patients with plasma HIV-1 RNA ≥50 copies/mL at week 48.3Benn P et al. Abstract P017. Presented at HIV Glasgow 2020. The secondary endpoint was proportion of patients with plasma HIV-1 RNA <50 copies/mL.[mfn referencenumber=3]Benn P et al. Abstract P017. Presented at HIV Glasgow 2020.[/mfn]

In total, 280 women were randomised and treated with CAB+RPV Q8W (n=137) and Q4W (n=143).3Benn P et al. Abstract P017. Presented at HIV Glasgow 2020. Of these women, 56% were white, with a median age of 44 years, and 53% were CAB+RPV-naïve.3Benn P et al. Abstract P017. Presented at HIV Glasgow 2020. In the Q8W and Q4W groups, 3.6% and 0% of women respectively, had HIV-1 RNA ≥50 copies/mL.3Benn P et al. Abstract P017. Presented at HIV Glasgow 2020. In both arms 91% of women had HIV-1 RNA <50 copies/mL.[mfn referencenumber=3]Benn P et al. Abstract P017. Presented at HIV Glasgow 2020.[/mfn] Five women developed confirmed virologic failure, with none occurring after week 24, and four out of these five had archived NNRTI resistance associated mutations.3Benn P et al. Abstract P017. Presented at HIV Glasgow 2020.

Amongst women with prior CAB+RPV exposure in the Q8W arm, 88% preferred the Q8W dose, compared with 8% and 2% of the Q4W and oral doses, respectively.3Benn P et al. Abstract P017. Presented at HIV Glasgow 2020. The safety profile was similar in both treatment arms, with mild to moderate injection site reactions that lasted a median duration of three to four days.3Benn P et al. Abstract P017. Presented at HIV Glasgow 2020. Fewer than 4% of the study population discontinued due to adverse events.3Benn P et al. Abstract P017. Presented at HIV Glasgow 2020. Women without prior CAB+RPV experience reported increased treatment satisfaction.3Benn P et al. Abstract P017. Presented at HIV Glasgow 2020.

The results of this subgroup analysis indicate that the long-acting combination of CAB+RPV is effective in women, well tolerated, and with high satisfaction rates.3Benn P et al. Abstract P017. Presented at HIV Glasgow 2020.


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Personalised Angina Treatment at Cellular Level
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23 December 2021

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Reference

  1. Nachman S et al. Lancet HIV. 2019;6(8):e552-e558.
  2. Trezza C et al. Curr Opin HIV AIDS. 2015;10(4):239-245.
  3. Benn P et al. Abstract P017. Presented at HIV Glasgow 2020.

Disclaimer

This article is not medical advice. Patients should seek personal assessment by a licenced specialist. Physicians are recommended to read the full publication(s) as cited in the article before making medical decisions. This article does not supersede nor replace the published article(s).

© Copyright 2020 MediPaper Medical Communications Ltd. – Cabotegravir and rilpivirine intramuscular combination safe in women

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We also use different external services like Google Webfonts, Google Maps and external Video providers. Since these providers may collect personal data like your IP address we allow you to block them here. Please be aware that this might heavily reduce the functionality and appearance of our site. Changes will take effect once you reload the page.

Google Webfont Settings:

Google Map Settings:

Vimeo and Youtube video embeds:

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