Larotrectinib Exceeds 90% Response Rate in TRK+ Pediatric Cancers
Larotrectinib induced an “unprecedented” objective response rate of 93% in patients with TRK fusion–positive solid tumors.
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Larotrectinib induced an “unprecedented” objective response rate of 93% in patients with TRK fusion–positive solid tumors.
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Based on data from 2 clinical trials, nilotinib (Tasigna) has been approved by the FDA for the first- and 2nd-line treatment of pediatric patients aged 1 year and older with Philadelphia chromosome–positive chronic myeloid leukemia in the chronic phase.
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It is indicated for prevention of nausea and vomiting associated with highly and moderately emetogenic chemotherapy in adult and paediatric patients
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It is indicated in adult and paediatric patients in first or second complete remission with minimal residual disease
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This survey is organised by the ESMO/SIOPE Cancer in Adolescent and Young Adults (AYA) Working Group following successful mapping of the European AYA cancer care landscape.
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A functional social network index was developed that is specific for adolescent and young adult survivors of cancer
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A rolling new drug application has been completed for larotrectinib (LOXO-101) for the treatment of adult and pediatric patients with locally advanced or metastatic solid tumors harboring an NTRK gene fusion.
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2018-03-28 22:16:00
Approval is based on results in paediatric patients from CAMN107A2120 and CAMN107A2203 studies