Lung Cancer (NSCLC & SCLC) Archives

U.S. FDA approved immunecheckpoint inhibitors U.S. FDA approved immunotherapies for cancer U.S. FDA approved immunotherapies for cancer

U.S. FDA Approved Immune-Checkpoint Inhibitors Updated 18-Jun-2018

June 18, 2018/3 Comments/in AE and irAE Management, Chemotherapy, Gastrointestinal Cancer, Genitourinary Cancer, Haematology, Head and Neck Cancer, ImmunoOncology, Immunotherapy, Lung Cancer, Melanoma Skin Cancer, Oncology, Targeted Therapies /by Stijn van den Borne, MSc

Since 2011, when the United States Food and Drug Administration (U.S. FDA) approved ipilimumab (Yervoy®) for malignant melanoma, several immune-checkpoint inhibitors have been granted marketing authorisation. Do you know all the indications? MediPaper made an overview of all the U.S. FDA approved immune-checkpoint inhibitors and other U.S. FDA approved immunotherapies.

IMPower150 Reck Socinski ELCC AACR 2018 firstline atezolizumab bevacizumab chemotherapy non-squamous nsclc

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AACR 2018: first-line atezolizumab, bevacizumab plus chemotherapy active in non-squamous NSCLC

May 10, 2018/2 Comments/in Chemotherapy, ImmunoOncology, Immunotherapy, Lung Cancer, Oncology, Translational Research /by Stijn van den Borne, MSc

First-line atezolizumab plus bevacizumab, carboplatin and paclitaxel improves PFS in patients with non-squamous NSCLC. Two presentations on the IMPower150 study by Martin Reck (ELCC 2018) and Mark Socinski (AACR 2018) discussed the frontline addition of atezolizumab to bevacizumab and chemotherapy in different lung cancer subgroups (NCT02366143).

AACR 2018 First-line Nivolumab-Ipilimumab in TMB-high NSCLC front-line immunotherapy for non-small cell lung cancer tumour-mutation burden CheckMate 227 NCT02477826

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Nivolumab-Ipilimumab Combination: A New Option for TMB-High NSCLC (CheckMate 227)

April 21, 2018/2 Comments/in Chemotherapy, ImmunoOncology, Immunotherapy, Lung Cancer, Oncology, Translational Research /by Stijn van den Borne, MSc

AACR 2018: First-line nivolumab-ipilimumab in TMB-high NSCLC with was associated with a more than tripled 1-year progression-free survival (PFS) rate compared to platinum-based chemotherapy in the Phase III CheckMate 227 trial (NCT02477826).

NCT02578680 Keynote189 AACR 2018 pembrolizumab chemotherapy nsclc NEJM Leena Gandhi

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Frontline Combination of Pembrolizumab and Chemotherapy: A New Standard of Care for Non-squamous NSCLC

April 19, 2018/1 Comment/in Chemotherapy, ImmunoOncology, Immunotherapy, Lung Cancer, Oncology, Translational Research /by Stijn van den Borne, MSc

AACR 2018: Frontline pembrolizumab plus chemotherapy in NSCLC reduces the risk of death by more than 50%. The Phase III KEYNOTE-189 trial combined pembrolizumab (Keytruda®) plus standard of care platinum-based chemotherapy in non-squamous non–small cell lung cancer (NSCLC) without EGFR or ALK genetic aberrations (NCT0278680)

Keynote-042 Keynote-024 pembrolizumab nsclc keytruda nsclc non-squamous squamous PD-L1 expression 1% 20% 50% Tony Mok MD NCT02220894 Pembrolizumab effective in frontline NSCLC with low PD-L1 expression

Pembrolizumab effective in frontline NSCLC with low PD-L1 expression

April 10, 2018/2 Comments/in Chemotherapy, ImmunoOncology, Immunotherapy, Lung Cancer, Oncology, Translational Research /by Stijn van den Borne, MSc

Pembrolizumab (Keytruda®) as single-agent immunotherapy in the frontline setting of any histology NSCLC with a PD-L1 expression ≥1% was associated with improved overall survival (OS) when compared to platinum-doublet chemotherapy in the KEYNOTE-042.

Crizotinib beneficial for East-Asian NSCLC patients with ROS1 alterations

April 4, 2018/1 Comment/in China, Lung Cancer, Oncology, Targeted Therapies /by Stijn van den Borne, MSc

Crizotinib in Asian NSCLC patients with ROS1 alterations was associated with a 71.7% objective response rate (ORR) with a median duration of response (DOR) of 19.7 months (95% CI, 14.1 months - not reached). Learn more about the results with crizotinib in East-Asian non-small cell lung cancer (NSCLC) patients harbouring c-ros oncogene 1 (ROS1) rearrangements.

Making sense of 1st-line immunotherapy in non-small cell lung cancer (NSCLC)

March 26, 2018/2 Comments/in Guidelines, ImmunoOncology, Immunotherapy, Lung Cancer, Oncology /by Stijn van den Borne, MSc

The expansion of therapeutic options with immunotherapies will reflect a dramatic change in the guidelines for lung cancer, where immunotherapies mostly compete with the use of chemotherapeutic agents. A brief communication on immunotherapies for NSCLC.