What is new in the treatment of genitourinary (GU) cancer? Read our genitourinary cancer blog and learn more about the latest advancements in the treatment of testicular, urothelial (bladder), renal (kidney), and prostate cancer.

U.S. FDA approved immunecheckpoint inhibitors U.S. FDA approved immunotherapies for cancer U.S. FDA approved immunotherapies for cancer

U.S. FDA Approved Immune-Checkpoint Inhibitors Updated 23-Apr-2018

Since 2011, when the United States Food and Drug Administration (U.S. FDA) approved ipilimumab (Yervoy®) for malignant melanoma, several immune-checkpoint inhibitors have been granted marketing authorisation. Do you know all the indications? MediPaper made an overview of all the U.S. FDA approved immune-checkpoint inhibitors and other U.S. FDA approved immunotherapies.

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Achieving Long-Term Survival in the First-Line Treatment of Metastatic Renal Cell Carcinoma; A Balancing Act of Efficacy and Side-Effects

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Nivolumab Renal Cell Cancer Symposium Highlight

Nivolumab for Renal Carcinoma: Getting the Most Out of PD-1 Immunotherapy

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PD-L1 Biomarker for Response DAKO 22C3 - MediPaper Medical Communications

PD-L1 Biomarker: a Comparison of ASCO2016 PD-1 and PD-L1 Data

The United States Food and Drug Agency (US FDA) require the development of companion diagnostics (CDx). CDx can help to identify patients at risk and guide patient selection. Moreover, it serves as a marker for treatment outcome. Thus enabling physicians to better balance safety with efficacy. The US FDA motivates the development of a CDx in early stages of clinical studies.

ESMO 2016 durvalumab avelumab tremelimumab data medipaper medical communications

ESMO16 Durvalumab, Avelumab, Tremelimumab Data - Download the PPT

Avelumab and durvalumab both are PD-L1 targeted antibodies, similar to atezolizumab (Tecentriq™), which was recently approved by the US FDA. Tremelimumab is a CTLA-4 inhibitor, similar to ipilimumab. It is a drug with a long history and also known as CP-675,206 and ticilimumab. The drug has been extensively investigated with mixed results.

ESMO 2016 atezolizumab data medipaper medical communications

ESMO16 Atezolizumab data - Download the PPT

ESMO 2016 atezolizumab data is focussed on lung cancer, melanoma, and urothelial cancer. Data includes cohort 1 of the Phase II IMvigor 210 Study in first-line metastatic Urothelial Cancer (mUC). The latest U.S. FDA approved indication for atezolizumab was Metastatic Urothelial Cancer in May 2016.

ESMO 2016 nivolumab data medipaper medical communications

ESMO16 Nivolumab data - Download the PPT

ESMO 2016 nivolumab data in Late Breaking Abstracts is focused on two studies in non-small cell lung cancer (NSCLC; CheckMate 026 and a neoadjuvant study), one presentation in combination with ipilimumab in stage 3 palpable melanoma (OpACIN trial), and finally a presentation in metastatic urothelial carcinoma (mUC; CheckMate-275 trial).