Tag Archive for: NSCLC

Sotorasib-for-the-treatment-of-KRASG12C-mutated-lung-cancer

Sotorasib approved as the first targeted therapy for KRAS-Mutant Lung Cancer

Lung cancer is one of the leading cancers in Hong Kong, accounting for 26.4% of cancer mortality in 2018. Approximately 80% of the lung cancers are non-small cell lung cancer (NSCLC).

Amivantamab-in-combination-with-Lazertinib-showed-efficacy-in-NSCLC

Amivantamab in combination with Lazertinib showed efficacy in NSCLC

Non-small cell lung cancer (NSCLC) accounts for 80-85% of all lung cancer. The most frequent genetic mutation harboured in lung adenocarcinomas occurs in the epidermal growth factor receptor (EGFR), accounting for 40-55% in Asian patients.

Lung-Cancer-Update-April-2021

Lung Cancer Update April 2021

With the World Conference on Lung Cancer (WCLC) 2020 completed last January, several new and clinical relevant phase 2 and phase 3 studies on Lung Cancer have been published. We summarised some key data for you.

cabotegravir-and-rilpivirine-intramuscular-combination-safe-in-women

Cabotegravir and rilpivirine intramuscular combination safe in women

Women account for a disproportionate percentage of new human immunodeficiency virus (HIV) infections in sub-Saharan Africa, comprising 59% of 18 million new adult HIV infections in 2017.

hcv-infected-kidneys-safe-for-transplantation-with-antiviral-treatment

HCV-infected kidneys safe for transplantation with antiviral treatment

Kidney transplants are the best treatment for end-stage renal disease (ESRD), with better survival outcomes than haemodialysis or peritoneal dialysis. However, in Hong Kong as well as much of the rest of the world, there is an increasing gap between the number of patients requiring a transplant and the number of organs available.

baloxavir-marboxil-recommended-as-post-exposure-prophylaxis-to-influenza-by-ema

Baloxavir marboxil recommended as post-exposure prophylaxis to influenza by EMA

Seasonal influenza is common between January to March, and July to August in Hong Kong. Baloxavir marboxil is the first influenza antiviral with a novel mechanism of action to be approved in almost two decades, and was registered for use in Hong Kong in February 2019.

U.S.-FDA-approved-immunecheckpoint-inhibitors-e1528902398517

US FDA approved immune-checkpoint inhibitors updated 08-Dec-2020

Know all the United States Food and Drug Administration (U.S. FDA) approved immune-checkpoint inhibitors. Members of MediPaper can download the free PPT slides summarising the U.S. FDA approved immune-checkpoint inhibitors and other U.S. FDA approved immunotherapies.

Sotorasib-for-the-treatment-of-KRASG12C-mutated-lung-cancer

Sotorasib for the treatment of KRASG12C mutated lung cancer

RAS is the most frequently mutated gene family in cancers, with KRAS mutations being involved as a driver in three of the most lethal cancers – lung cancer, colorectal cancer, and pancreatic cancer. Incidence of KRAS mutations vary between ethnicity with Caucasians having a higher incidence than African-Americans or Asians. In non-small lung cancer (NSCLC), the most common KRAS mutation is G12C. In Asia, G12C mutations in particular account for 14.5% of KRAS mutations in the Chinese population. KRAS G12C was identified in 4.3% of lung cancer samples and 2.5% of colorectal cancer samples.

Capmatinib-therapy-for-the-treatment-of-MET-positive-non-small-cell-lung-cancer

Capmatinib therapy for the treatment of MET-positive non-small cell lung cancer

A number of tyrosine kinase inhibitors (TKIs) are now available for the treatment of various types of non-small cell lung cancers (NSCLC), including epidermal growth factor receptor (EGFR)-mutated and anaplastic lymphoma kinase (ALK)-rearranged NSCLC. However, amplification of the MET gene, which codes for the hepatocyte growth factor receptor (HGFR), has been found to be one of the most prominent mechanisms of secondary resistance to EGFR TKIs. Similarly, the MET exon 14 (METex14) mutation has also emerged as a potential tumour driver due to its role in cancer proliferation, and thus also a promising target for NSCLC.

Selpercatinib-displays-efficacy-in-RET-fusion-positive-non-small-cell-lung-cancer

Selpercatinib displays efficacy in RET fusion-positive non-small cell lung cancer

Aberrant RET activation has shown to be a clinical driver of tumour growth and proliferation. It is reported that 1-2% of non-small cell lung cancer patients have activating RET fusions. Clinical characteristics of these patients are generally younger (<60 years) with minimal or no smoking history, and frequent presentation with brain metastases at diagnosis of advanced disease. RET mutations are mutually exclusive with other common lung cancer genetic abberations, such as reported for KRAS, EGFR, and ALK.