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IMMUNO-ONCOLOGY ARTICLES

U.S. FDA approved immunecheckpoint inhibitors U.S. FDA approved immunotherapies for cancer U.S. FDA approved immunotherapies for cancer

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July 19, 2018/by Stijn van den Borne, MSc

U.S. FDA Approved Immune-Checkpoint Inhibitors Updated 19-Jun-2018

Since 2011, when the United States Food and Drug Administration (U.S. FDA) approved ipilimumab (Yervoy®) for malignant melanoma, several immune-checkpoint inhibitors have been granted marketing authorisation. Do you know all the indications? MediPaper made an overview of all the U.S. FDA approved immune-checkpoint inhibitors and other U.S. FDA approved immunotherapies.

ASCO 2018 nsclc immunotherapy ASCO18 lung cancer pembrolizumab avelumab nivolumab duravalumab ipilimumab osimertinib dacomitinib lorlatinib crizotinib alectinib keytruda KEYNOTE CheckMate JAVELIN IMpower

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June 25, 2018/by Anne John Michael

ASCO 2018 NSCLC: The ASCO18 Lung Cancer Track Summarised

ASCO 2018 breast cancer TNBC MBC ABC ASCO18 PHEREXA D-CARE ABCSG-18 ASTRRA TEXT SOFT MONARCH-2 MONALEESA-3 SANDPIPER BOLERO-6 TOPACIO KEYNOTE-162 TONIC TOPACIO GeparNeuvo

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June 19, 2018/by Stijn van den Borne, MSc

ASCO 2018 Breast Cancer: The ASCO18 breast cancer track summarised

IMPower150 Reck Socinski ELCC AACR 2018 firstline atezolizumab bevacizumab chemotherapy non-squamous nsclc

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May 10, 2018/by Stijn van den Borne, MSc

AACR 2018: first-line atezolizumab, bevacizumab plus chemotherapy active in non-squamous NSCLC

US FDA approved CAR-t cell BiTE DAR-T cell CD19 Immunotherapies blinatumomab axicabtagene ciloleucel tisagenlecleucel

May 2, 2018/by Stijn van den Borne, MSc

US FDA approved CAR-T cell and BiTE immunotherapy - Updated 2-May-2018

ONCOLOGY ARTICLES

ASCO18 ASCO 2018 HCC hepatocellular carcinoma liver cancer pembrolizumab KEYTRUDA atezolizumab TECENTRIQ PD-1 PD-L1 immunecheckpoint immunotherapy ramucirumab cabozantinib KEYNOTE-224 SCRUM-Japan GI-SCREEN CELESTIAL REACH-2

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June 8, 2018/by Anne John Michael

ASCO 2018 HCC: The ASCO18 hepatocellular cancer track summarised

This year’s American Society of Clinical Oncology (ASCO) annual meeting includes two Phase III studies in the second-line treatment of the disease. Moreover, data with several immune-checkpoint inhibitors were presented, including the KEYNOTE-224 with pembrolizumab. Welcome to the summary of the ASCO 2018 HCC track.

AACR 2018 First-line Nivolumab-Ipilimumab in TMB-high NSCLC front-line immunotherapy for non-small cell lung cancer tumour-mutation burden CheckMate 227 NCT02477826

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April 21, 2018/by Stijn van den Borne, MSc

Nivolumab-Ipilimumab Combination: A New Option for TMB-High NSCLC (CheckMate 227)

NCT02578680 Keynote189 AACR 2018 pembrolizumab chemotherapy nsclc NEJM Leena Gandhi

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April 19, 2018/by Stijn van den Borne, MSc

Frontline Combination of Pembrolizumab and Chemotherapy: A New Standard of Care for Non-squamous NSCLC

Keynote-042 Keynote-024 pembrolizumab nsclc keytruda nsclc non-squamous squamous PD-L1 expression 1% 20% 50% Tony Mok MD NCT02220894 Pembrolizumab effective in frontline NSCLC with low PD-L1 expression

April 10, 2018/by Stijn van den Borne, MSc

Pembrolizumab effective in frontline NSCLC with low PD-L1 expression

Herbert Loong on irAEs Immunotherapy (I-O) and New Onset Diabetes or immune-mediated diabetes

April 6, 2018/by Stijn van den Borne, MSc

I-O in Special Populations: Diabetes and Concomitant Steroids

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irAE immune-related adverse events immune-mediated adverse events hepatitis pneumonitis rash diabetes_small

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CONFERENCE HIGHLIGHTS

ASCO 2018 ASCO18 pembrolizumab nivolumab durvalumab atezolizumab avelumab ipilimumab tremelimumab olaparib rucaparib niraparib PARP palbociclib ribociclib abemaciclib CDK46 osimertinib cabozantinib lenvatinib lorlatinib

©American Society for Clinical Oncology (ASCO)

aacr2018 american association for cancer research annual meeting 2018 AACR 2018 AACR annual meeting 2018

©American Association for Cancer Research

CSA2017-0-中华医学会第25-次全国麻醉学术年会-2017-郑州-25th-Annual-Meeting-of-the-Chinese-Society-of-Anaesthesiology

©Chinese Society for Anesthesiology

© European Society for Medical Oncology

ASCO 2016 annual meeting

©American Society of Clinical Oncology

©American College of Cardiology

ONCOLOGY ARTICLES (Cont’d)

Crizotinib beneficial for East-Asian NSCLC-patients with ROS1 alterations crizotinib asian crizotinib ros1 crizotinib asian nsclc patients crizotinib asian non-small cell lung cancer patients

April 4, 2018/by Stijn van den Borne, MSc

Crizotinib beneficial for East-Asian NSCLC patients with ROS1 alterations

Crizotinib in Asian NSCLC patients with ROS1 alterations was associated with a 71.7% objective response rate (ORR) with a median duration of response (DOR) of 19.7 months (95% CI, 14.1 months - not reached). Learn more about the results with crizotinib in East-Asian non-small cell lung cancer (NSCLC) patients harbouring c-ros oncogene 1 (ROS1) rearrangements.

immunotherapy I-O immunooncology nivolumab npc opdivo nasopharyngeal carcinoma brigette ma CUHK phase II nci-9742 study JCO journal of clinical oncology

March 31, 2018/by Stijn van den Borne, MSc

Nivolumab for NPC: immunotherapy active in nasopharyngeal carcinoma (NCI-9742)

Making sense of immunotherapy in NSCLC

March 26, 2018/by Stijn van den Borne, MSc

Making sense of 1st-line immunotherapy in non-small cell lung cancer (NSCLC)

Symposium Highlight 5HT3 NK1 Palonosetron Netupitant CINV Chemotherapy-induced Nausea and Vomiting

January 30, 2018/by Stijn van den Borne, MSc

Advances in the Prophylaxis of Chemotherapy-Induced Nausea and Vomiting: From Multi-Dose to Single Dose Control

manuela schmidinger sutent sunitinib ae management manuela schmidinger manuela schmidinger sutent sunitinib side-effect management sutent sunitinib toxicity management Sutent Sunitinib AE management toxicity management side-effect management sorafenib pazopanib axitinib regorafenib vandetanib cabozantinib lenvatinib bevacizumab VEGFR VEGF renal cell carcinoma RCC kidney cancer renal cell cancer schmidinger

November 29, 2017/by Stijn van den Borne, MSc

Achieving Long-Term Survival in the First-Line Treatment of Metastatic Renal Cell Carcinoma; A Balancing Act of Efficacy and Side-Effects

2016 pancreatic cancer awareness month IMM-101 plus Gemcitabine medipaper medical communications medical writer hire healthcare writers hong kong

November 20, 2017/by Stijn van den Borne, MSc

Do you know your lifetime risk on Pancreatic Cancer?

HKBCF luminal breast cancer can cdk46 inhibition by palbociclib improve on chemotherapy medipaper medical writer hong kong

October 25, 2017/by Stijn van den Borne, MSc

Luminal Breast Cancer: can CDK4/6 Inhibition by Palbociclib Improve on Chemotherapy?

Nivolumab Renal Cell Cancer Symposium Highlight

September 19, 2017/by Stijn van den Borne, MSc

Nivolumab for Renal Carcinoma: Getting the Most Out of PD-1 Immunotherapy

adjuvant hormonal therapy

July 5, 2017/by Stijn van den Borne, MSc

Should all Women with Endocrine-Sensitive and Operable Breast Cancer Receive Adjuvant Hormonal Therapy?

2017 CICS immunooncology annual meeting oncology medical writer medipaper medical communications

June 21, 2017/by Stijn van den Borne, MSc

Interested in Attending an Immunooncology Conference?

Latest global trends of health measure and impact on survival rate

August 16, 2017/by Stijn van den Borne, MSc

Latest global trends of health measure and impact on survival rate

Lack of strength and diabetes are becoming epidemic in the ageing population, and patients often ignore early signs and are unaware how to prevent these problems.

scientific symposium highlights optimisation of aerosol delivery in patients with poor asthma control aerosol delivery asthma

July 18, 2017/by Stijn van den Borne, MSc

Optimisation of aerosol delivery in patients with poor asthma control

AMNOG Germany Pharmaceuticals Pricing Legislation MediPaper Medical Writer Hong Kong

December 15, 2016/by Stijn van den Borne, MSc

AMNOG: Germany Pharmaceuticals Pricing Legislation Overview

asco 2016 nivolumab medipaper medical communications

May 29, 2016/by Stijn van den Borne, MSc

ASCO16 Nivolumab (Opdivo©) Data

asco 2016 immune checkpoint inhibitors

April 4, 2016/by Stijn van den Borne, MSc

ACC2016: 8½ Important Cardiology Lessons Learned

Ribociclib FDA label updated to include pre- and perimenopausal women

©United States Food and Drug Agency

July 23, 2018/by Stijn van den Borne, MSc

Ivosidenib FDA approved for relapsed or refractory acute myeloid leukemia

Ribociclib FDA label updated to include pre- and perimenopausal women

©United States Food and Drug Agency

July 19, 2018/by News Feed

Ribociclib FDA label updated to include pre- and perimenopausal women

FDA approved enzalutamide (XTANDI, Astellas Pharma US, Inc.), for patients with castration-resistant prostate cancer (CRPC). More Information. July 13, 2018

July 17, 2018/by News Feed

Enzalutamide FDA approved for castration-resistant prostate cancer (CRPC)

Ribociclib FDA label updated to include pre- and perimenopausal women

©United States Food and Drug Agency

July 11, 2018/by News Feed

Ipilimumab plus nivolumab FDA approved for MSI-H and dMMR pre-treated mCRC

Ribociclib FDA label updated to include pre- and perimenopausal women

©United States Food and Drug Agency

July 2, 2018/by News Feed

Combination encorafenib plus binimetinib for unresectable/metastatic BRAF V600E or V600K-positive melanoma FDA approved

FDA has limited the use of Tecentriq and Keytruda for patients with locally advanced or metastatic urothelial cancer who are not eligible for cisplatin-containing therapy. More Information. June 19, 2018

June 19, 2018/by News Feed

FDA limits use of atezolizumab and pembrolizumab in urothelial carcinoma

Ribociclib FDA label updated to include pre- and perimenopausal women

©United States Food and Drug Agency

June 14, 2018/by News Feed

Bevacizumab in combination with carboplatin and paclitaxel FDA approved for several types of gynaecological cancers

Ribociclib FDA label updated to include pre- and perimenopausal women

©United States Food and Drug Agency

June 14, 2018/by News Feed

FDA approved pembrolizumab for 3rd-line PMBCL in adult and pediatric patients

Ribociclib FDA label updated to include pre- and perimenopausal women

©United States Food and Drug Agency

June 13, 2018/by News Feed

FDA approved pembrolizumab for chemotherapy-refractory r/m cervical cancer with PD-L1 CPS ≥1

Ribociclib FDA label updated to include pre- and perimenopausal women

©United States Food and Drug Agency

June 9, 2018/by News Feed

FDA approves venetoclax in 2nd-line for patients with CLL or SLL

Ribociclib FDA label updated to include pre- and perimenopausal women

©United States Food and Drug Agency

June 6, 2018/by News Feed

FDA approved biosimilar pegfilgrastim to decrease the chance of febrile neutropenia in patients with non-myeloid cancers on myelosuppressive chemotherapy

Ribociclib FDA label updated to include pre- and perimenopausal women

©United States Food and Drug Agency

May 21, 2018/by News Feed

FDA approved avatrombopag for thrombocytopenia in CLD patient scheduled for a procedure

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