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IMMUNO-THERAPY

AACR 2018: FRONTLINE COMBINATION OF PEMBROLIZUMAB AND CHEMOTHERAPY: A NEW STANDARD OF CARE FOR NON-SQUAMOUS NSCLC

Medical writer: Stijn van den Borne, MSc | Last updated: 19th April 2018 | In: Chemotherapy, ImmunoOncology, Immunotherapy, Lung Cancer, Oncology, Translational Research

Article Keywords

AACR 2018, carboplatin, chemotherapy, cisplatin, Keytruda, Merck, non-squamous cell lung cancer, NSCLC, Oncology, Oncology News, PD-1, PD-L1, pembrolizumab, pemetrexed, TPS

Frontline pembrolizumab (KeytrudaⓇ) plus standard platinum-based chemotherapy reduces the risk of death by more than 50% in patients with non-squamous non–small cell lung cancer (NSCLC) not harbouring EGFR or ALK genetic aberrations, as shown by the Phase III KEYNOTE-189 trial which was presented at the 2018 AACR Annual Meeting with simultaneous publication in the New England Journal of Medicine.

“Pembrolizumab plus pemetrexed and platinum may be a new standard of care for first-line treatment of metastatic non-squamous NSCLC, irrespective of PD-L1 expression.”

~Leena Gandhi, MD

The double-blind, randomised-controlled, Phase III KEYNOTE-189 study recruited 616 treatment-naïve advanced and metastatic non-squamous NSCLC patients to receive frontline pembrolizumab or placebo (2:1) in combination with pemetrexed and investigator-choice cisplatin or carboplatin. Patients could enrol regardless of PD-L1 expression status but were required to be EGFR– and ALK-negative.

All patients received induction chemotherapy of pemetrexed 500 mg/m2 plus either cisplatin 75 mg/m2 or carboplatin (AUC 5) on day 1 every 3 weeks for 4 cycles plus pembrolizumab at a fixed dose of 200 mg every 3 weeks or matching placebo. Maintenance pemetrexed was offered to all patients at 500 mg/m2 every 3 weeks. Additionally, patients received 200 mg of pembrolizumab or matching placebo.

Overall Survival

At the time of data cut-off in November 2017, the median follow-up was 10.5 months. In the pembrolizumab-arm, the estimated 12-month OS rate was 69.2% (95% confidence interval [CI], 64.1-73.8) compared to 49.4% (95% CI, 42.1-56.2) in the placebo group (hazard ratio [HR]=0.49, P<0.001; 95% CI, 0.38-0.64).

The median OS was not reached in patients receiving pembrolizumab plus chemotherapy. In the group receiving placebo plus chemotherapy, the median OS was 11.3 months (95% CI, 8.7-15.1) in the chemotherapy-alone arm. The observed OS benefit was irrespective of PD-L1 expression status.

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NCT02578680 Keynote189 AACR 2018 pembrolizumab chemotherapy nsclc NEJM Leena Gandhi overall survival
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12-month OS-rate Pembrolizumab + Chemotherapy: 69.2% (95%CI, 64.1-73.8)
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mOS Pembrolizumab + Chemotherapy: not reached

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12-month OS-rate Placebo + Chemotherapy: 49.4% (95%CI, 42.1-56.2)
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mOS Placebo + Chemotherapy: 11.3 months (95%CI, 8.7-15.1)

Figure 1. Kaplan-Meier estimate for OS in the KEYNOTE-189: pembrolizumab + chemotherapy was associated with a more than 50% reduction of risk of death (HR=0.49, P<0.001; 95% CI, 0.38-0.64) when compared to placebo + chemotherapy. mOS: median OS.


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“Adding pembrolizumab to pemetrexed and platinum induction therapy and pemetrexed maintenance therapy significantly improved overall survival, progression-free survival, and overall response rate, in patients with previously untreated metastatic non-squamous non–small cell lung cancer without EGFR or ALK alterations,”

~Leena Gandhi, MD

Progression-Free Survival

The co-primary endpoint of the study, progression-free survival (PFS), was also met. The median PFS for patients receiving the combination pembrolizumab + chemotherapy was 8.8 months (95%CI, 7.6-9.2). In patients receiving placebo + chemotherapy, the median PFS measured 4.9 months (95%CI, 4.7-5.5). Patients receiving the pembrolizumab-chemotherapy combination had a risk reduction of 48% for progression disease (HR=0.52, P<0.001; 95%CI, 0.43-0.64).

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NCT02578680 Keynote189 AACR 2018 pembrolizumab chemotherapy nsclc NEJM Leena Gandhi progression-free survival
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mPFS Pembrolizumab + Chemotherapy: 8.8 months (95% CI, 7.6-9.2)

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12-month PFS-rate Pembrolizumab + Chemotherapy: 34.1% (95% CI, 28.8-39.5)
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mPFS Placebo + Chemotherapy: 4.9 months (95% CI, 4.7-5.5)
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12-month PFS-rate Placebo + Chemotherapy: 17.3% (95% CI, 12.0-23.5)

Figure 2. Kaplan-Meier estimate for PFS in the KEYNOTE-189: pembrolizumab + chemotherapy was associated with a 48% reduction of risk of progression or death (HR=0.49, P<0.001; 95%CI, 0.38-0.64) when compared to placebo + chemotherapy. mPFS: median PFS.

Cross-Over Effect

Over 40% of patients (50% when excluding those still receiving treatment) allocated to the placebo-arm (N=206) crossed-over to receive Programmed Death 1 (PD-1)-directed therapy. The KEYNOTE-189 study allowed for cross-over and 67 patients made use of this option by receiving pembrolizumab after chemotherapy plus placebo. Another 18 patients received PD-1, and PD-1 ligand (PD-L1) directed therapy outside the KEYNOTE-189 protocol.

Translational Studies: PD-L1 Expression

In the KEYNOTE-189 study, the PD-L1 expression level was measured by tumour proportion score (TPS; % of tumour cells with membranous PD-L1 staining). Table 1 is an overview of the TPS score and related primary efficacy endpoint outcomes.

PD-L1 TPS GroupPatients N (%)median OS PEMBRO vs PBO12-month OS rate PEMBRO vs PBOmedian PFS PEMBRO vs PBO12-month PFS rate PEMBRO vs PBO
TPS >1%190 (31%)15.2 vs 12.0 months61.7% vs 52.2% (HR=0.59; 95%CI, 0.38-0.92)6.1 vs 5.1 months (HR=0.75; 95%CI, 0.53-1.05)19.1% vs 15.7%
TPS 1–49%186 (30%)NR vs 12.9 months71.5% vs 50.9% (HR=0.55; 95%CI, 0.34-0.90)9.0 vs 4.9 months (HR=0.55; 95%CI, 0.37–0.81)37.5% vs 19.6%
TPS ≥50%202 (33%)NR vs 10 months73.0% vs 48.1% (HR=0.42; 95%CI, 0.26-0.68) 9.4 vs 4.7 months (HR=0.36; 95%CI, 0.25–0.52)44.9% vs 15.4%

Table 1. Outcome of the primary efficacy endpoints in the KEYNOTE-189 study by PD-L1 level expression (tumour proportion score or TPS). TPS is the percentage of tumour cells with membranous PD-L1 staining. PEMBRO: pembrolizumab + chemotherapy group; PBO: placebo + chemotherapy group.

Figure 3a. Response rates of pembrolizumab plus chemotherapy for non-squamous NSCLC (KEYNOTE-189).

    Figure 3b. Response rates of placebo plus chemotherapy for non-squamous NSCLC (KEYNOTE-189).

    Response Rate

    A significant difference (P<0.001) in objective response rate (ORR) by blinded, independent central radiologic review was observed between the pembrolizumab-chemotherapy group (ORR=47.6%; 95%CI, 42.6-52.5) and the placebo-chemotherapy group (ORR 18.9%; 95%CI, 13.8-25.0). The disease control rate (DCR) was 84.6% vs 70.4%, and the median duration of response (DOR) 11.2 months vs 7.8 months, both favouring the addition of pembrolizumab to chemotherapy.

    Safety

    Discontinuation of the study due to adverse events (AEs) was 13.8% in the pembrolizumab plus chemotherapy group and 7.9% for the placebo plus chemotherapy group. Just over 20% of participants discontinued pembrolizumab. In the placebo group 10.4% of participants discontinued the study. Death related to AEs occurred in 6.7% vs 5.9% for pembrolizumab vs placebo, respectively.

    Acute kidney injury was more frequently seen in the pembrolizumab arm (5.2%) vs the chemotherapy-alone arm (0.5%). Grade ≥3 acute kidney injury occurred in 8 patients (2.0%) receiving the PD-1 immunotherapy.

    The only two AEs in ≥10% of participants which were more frequently seen in the experimental arm than the control arm were diarrhoea (30.9% vs 21.3%) and rash (20.2% vs 11.4%). Other Grade ≥3 AEs occurring in ≥10% of patients in were anaemia 16.3% vs 15.3% and neutropenia 15.8% vs 11.9%, both for pembrolizumab vs placebo, respectively).

    Immune-mediated AEs (irAEs) occurred in 22.7% (all-grade) and 8.9% (Grade ≥3) of pembrolizumab-treated patients vs 11.9% (all-grade) and 4.5% (Grade ≥3) of patients receiving placebo. Three participants succumbed due to pneumonitis in the pembrolizumab-group.

    References

    1. Gandhi L et al. N Engl J Med. DOI: 10.1056/NEJMoa1801005.
    2. Gandhi L et al. Abstract CT075. Presented at 2018 AACR Annual Meeting; April 14-18, 2018.

    Figure 3a. Response rates of pembrolizumab plus chemotherapy for non-squamous NSCLC (KEYNOTE-189).

      Figure 3b. Response rates of placebo plus chemotherapy for non-squamous NSCLC (KEYNOTE-189).

      Disclaimer

      This article is not medical advice. Patients should seek personal assessment by a licenced specialist. Physicians are recommended to read the full publication(s) as cited in the article before making medical decisions. This article does not supersede nor replace the published article(s).

      © Copyright 2018 MediPaper Medical Communications Ltd. – AACR 2018: Combination pembrolizumab-chemotherapy for NSCLC: a New Standard of Care

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      https://medi-paper.com/wp-content/uploads/2019/12/Capivasertib-combined-with-paclitaxel-improves-survival-of-metastatic-triple-negative-breast-cancer-patients-e1582170747234.jpg 1000 1500 Christy HC CHEUNG, BSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Christy HC CHEUNG, BSc2020-02-11 17:30:382020-02-11 23:17:00Capivasertib plus paclitaxel improves survival of metastatic triple-negative breast cancer patients
      Olaparib plus Bevacizumab as Maintenance Therapy in Ovarian Cancer
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      Olaparib plus Bevacizumab as Maintenance Therapy in Ovarian Cancer

      https://medi-paper.com/wp-content/uploads/2019/12/Olaparib-plus-Bevacizumab-as-Maintenance-Therapy-in-Ovarian-Cancer.jpg 844 1500 Christy HC CHEUNG, BSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Christy HC CHEUNG, BSc2020-01-24 16:32:552020-01-24 16:40:07Olaparib plus Bevacizumab as Maintenance Therapy in Ovarian Cancer
      ADDING RIBOCICLIB TO FULVESTRANT IMPROVES THE SURVIVAL OF ADVANCED BREAST CANCER PATIENTS MONALEESA-3
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      Ribociclib plus Fulvestrant Improves Survival in Advanced Breast Cancer

      https://medi-paper.com/wp-content/uploads/2020/01/ADDING-RIBOCICLIB-TO-FULVESTRANT-IMPROVES-THE-SURVIVAL-OF-ADVANCED-BREAST-CANCER-PATIENTS-MONALEESA-3-scaled.jpg 1056 1500 Christy HC CHEUNG, BSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Christy HC CHEUNG, BSc2020-01-12 23:33:152020-01-13 10:41:47Ribociclib plus Fulvestrant Improves Survival in Advanced Breast Cancer
      ASCO 2019 lung cancer NSCLC ASCO19 SCLC mesothelioma KEYNOTE-189 KEYNOTE-001 IMpower150 MYSTIC LCMC3 Lung-MAP S1400G S1400I Flaura CALGB 30901 DETERRED COMPASS
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      ASCO 2019 Lung Cancer: 36 Oral Presentations of the ASCO19 lung cancer track summarised

      https://medi-paper.com/wp-content/uploads/2019/06/ASCO-2019-lung-cancer-NSCLC-ASCO19-SCLC-mesothelioma-KEYNOTE-189-KEYNOTE-001-IMpower150-MYSTIC-LCMC3-Lung-MAP-S1400G-S1400I-Flaura-CALGB-30901-DETERRED-COMPASS-.png 1000 750 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-06-12 14:12:322019-06-12 16:51:35ASCO 2019 Lung Cancer: 36 Oral Presentations of the ASCO19 lung cancer track summarised
      paclitaxel, cobimetinib, Cotellic, MEK, Exelixis, atezolizumab, Tecentriq, nab-paclitaxel pembrolizumab, Keytruda, Merck, MSD, eribulin mesylate, Halaven, pertuzumab, trastuzumab, Herceptin, Perjeta, docetaxel, Taxotere, Sanofi, trastuzumab-dkst, Ogivri, Mylan, Biocon, margetuximab, MacroGenics, capecitabine, Xeloda, Genentech, gemcitabine, Gemzar, vinolrebine, pyrotinib, Jiangsu HengRui Medicine, neratinib, Nerlynx, Puma, lapatinib, Tykerb, carboplatin, T-DM1, ado-trastuzumab emtansine, Kadcyla doxorubicin, cisplatin, olaparib, Lynparza, cyclophosphamide, epirubicin, Ellence, Pharmorubicin, letrozole, Femara, Novartis, AI, NSAI, capivasertib, capivasertib, AZD5363, AKT, hormonal therapy, endocrine therapy, CDK4/6, RAD001, mTOR, fulvestrant, Faslodex, abemaciclib, Verzenio, Eli Lilly, ribociclib, Kisqali, goserilin, Zoladex, AstraZeneca, everolimus, Afinitor, exemestane, Aromasin, Pfizer, palbociclib, Ibrance, #ASCO2019, AKT1, AZ, BRCA, chemotherapy, CNS metastases, ER-positive, ESR1, GnRH, HER2-negative, HER2-positive, HR-positive, LABC, neoadjuvant, OfS, PARP, PARPi, pCR, PD-L1, postmenopausal, PR-positive, premenopausal, RB1, TAC, taxane, TNBC, trastuzumab, triptorelin
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      ASCO 2019 Breast Cancer: The ASCO19 breast cancer track summarised

      https://medi-paper.com/wp-content/uploads/2019/05/ASCO-2019-breast-cancer-TNBC-MBC-ABC-ASCO19-MONALEESA-7-TRINITI-1-FAKTION-TBCRC030-NeoSTOP-ETNA-GeparOLA-KRISTINE-PREDIX-CLEOPATRA-HERITAGE-SOPHIA-NALA-IMpassion-130-Tapur-Colet.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-06-03 16:53:572019-06-04 14:34:55ASCO 2019 Breast Cancer: The ASCO19 breast cancer track summarised
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      Venetoclax FDA approved for CLL and SLL

      https://medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2019-05-15 16:19:292019-05-23 12:36:08Venetoclax FDA approved for CLL and SLL
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      FDA approves avelumab plus axitinib for renal cell carcinoma

      https://medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-05-14 16:22:572019-05-22 22:49:14FDA approves avelumab plus axitinib for renal cell carcinoma
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      Ramucirumab FDA approved for hepatocellular carcinoma

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      T-DM1 FDA approved for early breast cancer

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      Ivosidenib FDA-approved as first-line treatment for AML patients with IDH1 mutation

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      Can a novel, temporary, and fully resorbable surgical implant improve the outcome of common hockey and soccer injuries?
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      Can a novel, temporary, and fully resorbable surgical implant improve the outcome of common hockey and soccer injuries?

      https://medi-paper.com/wp-content/uploads/2019/04/Can-a-novel-temporary-and-fully-resorbable-surgical-implant-improve-the-outcome-of-common-hockey-and-soccer-injuries.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-04-26 20:05:262019-04-26 20:12:32Can a novel, temporary, and fully resorbable surgical implant improve the outcome of common hockey and soccer injuries?
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      Pembrolizumab plus axitinib FDA approved for the first-line treatment of advanced renal cell carcinoma patients

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      KEYNOTE-158 pembrolizumab in previously treated advanced cervical cancer
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      KEYNOTE-158: pembrolizumab in previously treated advanced cervical cancer

      https://medi-paper.com/wp-content/uploads/2019/04/KEYNOTE-158-pembrolizumab-in-previously-treated-advanced-cervical-cancer.jpg 844 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-04-24 18:22:142019-04-24 18:22:14KEYNOTE-158: pembrolizumab in previously treated advanced cervical cancer
      Atezolizumab with or without cobimetinib vs regorafenib for previously treated metastatic colorectal cancer IMblaze370
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      Atezolizumab +/- cobimetinib vs regorafenib for previously treated metastatic colorectal cancer (IMblaze370)

      https://medi-paper.com/wp-content/uploads/2019/04/Atezolizumab-with-or-without-cobimetinib-vs-regorafenib-for-previously-treated-metastatic-colorectal-cancer-IMblaze370.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-04-22 21:21:372019-04-22 21:57:04Atezolizumab +/- cobimetinib vs regorafenib for previously treated metastatic colorectal cancer (IMblaze370)
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      Palbociclib approved for the treatment of male breast cancer 

      https://medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2019-04-22 16:13:232019-04-22 21:56:34Palbociclib approved for the treatment of male breast cancer 
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      Erdafitinib FDA approved for the treatment of metastatic urothelial carcinoma

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      Atezolizumab FDA approved for extensive-stage small cell lung cancer (SCLC)

      https://medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2019-03-23 09:39:402019-03-23 09:41:21Atezolizumab FDA approved for extensive-stage small cell lung cancer (SCLC)
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      Atezolizumab FDA approved for PD-L1 positive unresectable triple-negative breast cancer

      https://medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2019-03-09 23:15:272019-03-09 23:15:27Atezolizumab FDA approved for PD-L1 positive unresectable triple-negative breast cancer
      Immunoncology I-O drugs and immunotherapy for renal cancer RCC
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      Combinations: upcoming treatment strategies in metastatic renal cell carcinoma

      https://medi-paper.com/wp-content/uploads/2019/02/Immunoncology-I-O-drugs-and-immunotherapy-for-renal-cancer-RCC-.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-03-05 11:13:432019-03-07 14:27:09Combinations: upcoming treatment strategies in metastatic renal cell carcinoma
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      Trifluridine/tipiracil combination FDA approved for metastatic gastric or GEJ adenocarcinoma

      https://medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2019-02-23 15:05:352019-03-08 17:00:25Trifluridine/tipiracil combination FDA approved for metastatic gastric or GEJ adenocarcinoma
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      Pembrolizumab FDA approved for adjuvant treatment of melanoma

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      Trastuzumab-biosimilar Ontruzant® FDA approved in several indications

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      Cabozantinib FDA approved in HCC patients failing sorafenib

      https://medi-paper.com/wp-content/uploads/2018/11/FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2019-01-17 10:35:362019-02-18 13:23:29Cabozantinib FDA approved in HCC patients failing sorafenib
      Erasmus University MC investigating a new surgical matrix to reduce post-operative complications
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      Erasmus University MC investigating a new surgical matrix to reduce post-operative complications

      https://medi-paper.com/wp-content/uploads/2019/01/Erasmus-University-MC-investigating-a-new-surgical-matrix-to-reduce-post-operative-complications.jpg 900 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-01-16 22:58:582019-01-16 23:09:21Erasmus University MC investigating a new surgical matrix to reduce post-operative complications
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      Keytruda® FDA approved for recurrent and metastatic Merkel cell carcinoma

      https://medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-01-14 15:36:172019-01-14 15:43:55Keytruda® FDA approved for recurrent and metastatic Merkel cell carcinoma
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      Calaspargase pegol-mknl (Asparlas®) FDA approved in paediatric and young adult acute lymphoblastic leukaemia (ALL) patients

      https://medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-12-27 16:16:402018-12-27 16:16:40Calaspargase pegol-mknl (Asparlas®) FDA approved in paediatric and young adult acute lymphoblastic leukaemia (ALL) patients
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      Elzonris™ FDA approved for blastic plasmacytoid dendritic cell neoplasm (BPDCN)

      https://medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-12-27 15:51:482018-12-27 15:53:57Elzonris™ FDA approved for blastic plasmacytoid dendritic cell neoplasm (BPDCN)
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      Olaparib (Lynparza) FDA approved as maintenance for BRCAm ovarian cancer

      https://medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-12-22 16:54:192018-12-22 16:54:19Olaparib (Lynparza) FDA approved as maintenance for BRCAm ovarian cancer
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      Trastuzumab-biosimilar Herzuma® FDA approved in HER2+ breast cancer

      https://medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-12-21 15:19:112018-12-21 15:32:40Trastuzumab-biosimilar Herzuma® FDA approved in HER2+ breast cancer
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      Frontline atezolizumab plus bevacizumab and chemotherapy FDA approved for metastatic non-squamous NSCLC

      https://medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-12-11 13:21:272018-12-11 13:22:23Frontline atezolizumab plus bevacizumab and chemotherapy FDA approved for metastatic non-squamous NSCLC
      MURANO: off-drug progression-free survival after 2 years venetoclax plus 6 cycles Rituximab
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      MURANO: off-drug progression-free survival after 2 years venetoclax plus 6 cycles Rituximab

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      TIGR®Matrix shows promising results when used for incisional hernia prevention in septic patients undergoing laparoscopy
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      TIGR®Matrix shows promising results when used for incisional hernia prevention in septic patients undergoing laparoscopy

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      Gilteritinib (Xospata®) FDA approved for relapsed or refractory AML harbouring FLT3 mutations

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      TKR inhibitor larotrectinib (Vitrakvi®) FDA approved for cancers with NTRK gene fusion

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      FDA Approves Truxima as Biosimilar to Rituxan

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      Venetoclax plus azacitidine, decitabine, or low-dose cytarabine FDA approved in elderly AML patients

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      Glasdegib plus low-dose cytarabine (LDAC) approved in elderly AML patients

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      Robert Lewandowski Y90 TARE TheraSphere The Emerging Role of Yttrium90 in Primary and Metastatic Liver Cancer hepatocellular carcinoma hcc
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      The Emerging Role of Yttrium-90 in Primary and Metastatic Liver Cancer

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      Emapalumab FDA approved in adult and paediatric patients with primary hemophagocytic lymphohistiocytosis

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      Brentuximab vedotin (Adcetris®) plus chemotherapy approved for several CD30 expressing lymphomas

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      Fully resorbable synthetic matrix offers improved safety for breast cancer patients undergoing immediate breast reconstruction
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      Fully resorbable synthetic matrix offers improved safety for breast cancer patients undergoing immediate breast reconstruction

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      Pembrolizumab FDA approved in hepatocellular carcinoma patients pretreated with sorafenib

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      Lorlatinib FDA approved for metastatic ALK-positive NSCLC

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      ESMO 2018 HCC ESMO18 Liver Cancer ESMO2018 hepatocellular carcinoma hepatobiliary cholangiocarcinoma BTC
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      ESMO 2018 HCC: The ESMO18 hepatobiliary cancer track summarised

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      Pembrolizumab plus chemotherapy approved for metastatic squamous NSCLC

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      Dr Joanne Chiu HKU management irAE hepatitis manage immune-mediated hepatitis immunotherapy I-O immunooncology immune-induced hepatitis
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      Management of Immune-Mediated Hepatitis: a Case Report

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      PARPi talazoparib FDA approved for deleterious gBRCAm HER2‑negative breast cancer

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      innovent biologics anti-pd1 sintilimab plus biosimilar bevacizumab receive ind status by china nmpa
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      Anti-PD1 sintilimab plus biosimilar bevacizumab receive IND-status by China NMPA

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      IMpower133 first-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer
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      IMpower133: first-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer

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      Pembrolizumab plus chemotherapy effective in squamous NSCLC
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      Pembrolizumab plus chemotherapy effective in squamous NSCLC

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      Ipilimumab plus nivolumab for persistent or recurrent ovarian cancer
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      Ipilimumab plus nivolumab for persistent or recurrent ovarian cancer

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      Brigatinib prolongs PFS compared to crizotinib in ALK-Positive NSCLC
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      Brigatinib prolongs PFS compared to crizotinib in ALK-Positive NSCLC

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      CAR-T axicabtagene ciloleucel granted Orphan Drug Designation for B-Cell Lymphoma by the Japan MHLW
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      CAR-T axicabtagene ciloleucel granted Orphan Drug designation for B-Cell Lymphoma by the Japan MHLW

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      PD-1 mAB cemiplimab FDA approved for locally advanced and metastatic cutaneous squamous cell carcinoma (CSCC)

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      JAVELIN Lung 200 avelumab vs docetaxel in patients with pretreated advanced non-small cell lung cancer NSCLC
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      JAVELIN Lung 200: avelumab vs docetaxel for pretreated NSCLC

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      Dacomitinib FDA approved for the first-line treatment of metastatic EGFR-mutated NSCLC

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      MediPr medipr.org medi-paper.com MediNews Asia MediNews.asia MediNews.cn MediPaper Medical Communications Ltd Healthcare Writers Medical Writers Medical Writer Agency Hong Kong Medical Writing Services Solutions Quote 醫學寫作 香港 醫學作家香港
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      ©United States Food and Drug Agency US FDA

      Duvelisib FDA approved for adult patients with R/R CLL or SLL

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      MediPr medipr.org medi-paper.com MediNews Asia MediNews.asia MediNews.cn MediPaper Medical Communications Ltd Healthcare Writers Medical Writers Medical Writer Agency Hong Kong Medical Writing Services Solutions Quote 醫學寫作 香港 醫學作家香港
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      ©United States Food and Drug Agency US FDA

      Duvelisib FDA approved for adult patients with R/R follicular lymphoma

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      Front-line atezolizumab plus chemotherapy improves PFS in NSCLC
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      Frontline atezolizumab plus chemotherapy improves PFS in NSCLC

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      First-line osimertinib vs EGFR-TKI in Asian patients with advanced NSCLC
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      First-line osimertinib vs EGFR-TKI in Asian patients with advanced NSCLC

      https://medi-paper.com/wp-content/uploads/2018/09/First-line-osimertinib-vs-EGFR-TKI-in-Asian-patients-with-advanced-NSCLC.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-09-24 13:24:282018-09-24 15:25:11First-line osimertinib vs EGFR-TKI in Asian patients with advanced NSCLC
      Early breast cancer treatment in China remains conservative
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      Early breast cancer treatment in China remains conservative

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      immuno-oncology I-O treatment for the irAE Rash
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      Quizartinib Receives Orphan Drug Designation for FLT3-Mutated AML in Japan
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      Quizartinib receives Orphan Drug designation for FLT3-mutated AML in Japan

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      Capmatinib plus gefitinib promising in MET-dysregulated NSCLC

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      CAR-TCR Summit 2018 Preliminary first-in-human data with CAR-Claudin18.2-T in gastric and pancreatic cancer
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      CAR-TCR Summit 2018: Preliminary first-in-human data with CAR-Claudin18.2-T in gastric and pancreatic cancer

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      DRIVER connects cancer patients in China and the United States to the best care
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      DRIVER connects cancer patients in China and the United States to the best care

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      Blood-based TMB-assay predicts response to atezolizumab in NSCLC patients
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      Plasma TMB predicts response to atezolizumab in NSCLC patients

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      First-in-Class Oncology Vaccine BIL06v Starts Phase 1 Evaluation
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      First-in-Class Oncology Vaccine BIL06v Starts Phase 1 Evaluation

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      Nivolumab FDA approved for patients with metastatic small cell lung cancer (SCLC)
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      Pembrolizumab and atezolizumab USPIs updated by FDA

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      Nivolumab FDA approved for patients with metastatic small cell lung cancer (SCLC)
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      Nivolumab FDA approved for patients with metastatic small cell lung cancer (SCLC)

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      Pembrolizumab plus pemetrexed-platinum approved for use in the 1st-line treatment of metastatic non-squamous NSCLC
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      Pembrolizumab plus pemetrexed-platinum FDA approved for first-line treatment of metastatic non-squamous NSCLC

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      Talazoparib in advanced breast cancer patients with a germline BRCA1:2 mutation
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      Talazoparib in advanced breast cancer patients with a germline BRCA1/2 mutation

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      CheckMate 032 Nivolumab ipilimumab metastatic esophagogastric cancer
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      CheckMate 032: Nivolumab +/- ipilimumab for metastatic esophagogastric cancer

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      Pembrolizumab plus pemetrexed-platinum approved for use in the 1st-line treatment of metastatic non-squamous NSCLC
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      Lenvatinib FDA approved for 1st-line treatment of HCC

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      Pan-EGFR TKI pirotinib has commenced into Phase II clinical testing in China
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      Pan-EGFR TKI pirotinib has commenced into Phase II clinical testing in China

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      FDA approved lusutrombopag (Mulpleta, Shionogi Inc.) for thrombocytopenia in adults with chronic liver disease who are scheduled to undergo a medical or dental procedure. More Information.  July 31, 2018.
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      FDA approved mogamulizumab for adult patients with relapsed or refractory CTCL

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      FDA approved lusutrombopag (Mulpleta, Shionogi Inc.) for thrombocytopenia in adults with chronic liver disease who are scheduled to undergo a medical or dental procedure. More Information.  July 31, 2018.
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      Lusutrombopag FDA approved for thrombocytopenia in adult chronic liver disease patients

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      Ribociclib FDA label updated to include pre- and perimenopausal women
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      Iobenguane I-131 FDA approved for rare adrenal neuroendocrine tumours

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      T790M osimertinib nsclc brain metastasis CNS metastases Osimertinib in patients With T790M-Positive Advanced Non-Small-Cell Lung Cancer and brain metastases AURA3
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      Osimertinib in patients with T790M-positive advanced non-small cell lung cancer and brain metastases (AURA3)

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      Anti-PD1 with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma
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      Anti-PD1 with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma

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      Ribociclib FDA label updated to include pre- and perimenopausal women
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      Ivosidenib FDA approved for relapsed or refractory acute myeloid leukemia

      https://medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-23 11:33:402018-07-30 10:43:08Ivosidenib FDA approved for relapsed or refractory acute myeloid leukemia
      FDA approved enzalutamide (XTANDI, Astellas Pharma US, Inc.), for patients with castration-resistant prostate cancer (CRPC). More Information.  July 13, 2018
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      Filgrastim-aafi FDA approved as Filgrastim Biosimilar

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      Ribociclib FDA label updated to include pre- and perimenopausal women
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      Ribociclib FDA label updated to include pre- and perimenopausal women

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      FDA approved enzalutamide (XTANDI, Astellas Pharma US, Inc.), for patients with castration-resistant prostate cancer (CRPC). More Information.  July 13, 2018
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      Enzalutamide FDA approved for castration-resistant prostate cancer (CRPC)

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      EBV pembrolizumab gastric cancer - MSI-H pembrolizumab gastric cancer - CPS pembrolizumab gastric cancer - MSI, EBV, CPS predict pembrolizumab outcome in gastric cancer
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      EBV, MSI, and CPS predict pembrolizumab outcome in gastric cancer

      https://medi-paper.com/wp-content/uploads/2018/08/EBV-pembrolizumab-gastric-cancer-MSI-H-pembrolizumab-gastric-cancer-CPS-pembrolizumab-gastric-cancer-MSI-EBV-CPS-predict-pembrolizumab-outcome-in-gastric-cancer.jpg 1000 1500 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-16 14:03:432018-08-31 08:15:52EBV, MSI, and CPS predict pembrolizumab outcome in gastric cancer
      Ribociclib FDA label updated to include pre- and perimenopausal women
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      Ipilimumab plus nivolumab FDA approved for MSI-H and dMMR pre-treated mCRC

      https://medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-11 20:52:132018-07-30 10:41:58Ipilimumab plus nivolumab FDA approved for MSI-H and dMMR pre-treated mCRC
      Ribociclib FDA label updated to include pre- and perimenopausal women
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      Combination encorafenib plus binimetinib for unresectable/metastatic BRAF V600E or V600K-positive melanoma FDA approved

      https://medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-02 22:14:052018-07-30 10:41:23Combination encorafenib plus binimetinib for unresectable/metastatic BRAF V600E or V600K-positive melanoma FDA approved
      ASCO 2018 nsclc immunotherapy ASCO18 lung cancer pembrolizumab avelumab nivolumab duravalumab ipilimumab osimertinib dacomitinib lorlatinib crizotinib alectinib keytruda KEYNOTE CheckMate JAVELIN IMpower
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      ASCO 2018 NSCLC: The ASCO18 Lung Cancer Track Summarised

      https://medi-paper.com/wp-content/uploads/2018/06/ASCO-2018-nsclc-immunotherapy-ASCO18-lung-cancer-pembrolizumab-avelumab-nivolumab-duravalumab-ipilimumab-osimertinib-dacomitinib-lorlatinib-crizotinib-alectinib-keytruda-KEYNOTE-CheckMate-JAVELIN-IMpower.jpg 1000 1500 Anne John Michael https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Anne John Michael2018-06-25 18:22:252018-08-21 11:43:54ASCO 2018 NSCLC: The ASCO18 Lung Cancer Track Summarised
      FDA  has limited the use of Tecentriq and Keytruda for patients with locally advanced or metastatic urothelial cancer who are not eligible for cisplatin-containing therapy.  More Information.  June 19, 2018
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      FDA limits use of atezolizumab and pembrolizumab in urothelial carcinoma

      https://medi-paper.com/wp-content/uploads/2018/07/FDA-has-limited-the-use-of-Tecentriq-and-Keytruda-for-patients-with-locally-advanced-or-metastatic-urothelial-cancer-who-are-not-eligible-for-cisplatin-containing-therapy.-More-Information-.-June-19-2018-e1537925445648.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-06-19 14:01:322018-07-30 10:40:51FDA limits use of atezolizumab and pembrolizumab in urothelial carcinoma
      ASCO 2018 breast cancer TNBC MBC ABC ASCO18 PHEREXA D-CARE ABCSG-18 ASTRRA TEXT SOFT MONARCH-2 MONALEESA-3 SANDPIPER BOLERO-6 TOPACIO KEYNOTE-162 TONIC TOPACIO GeparNeuvo
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      ASCO 2018 Breast Cancer: The ASCO18 breast cancer track summarised

      https://medi-paper.com/wp-content/uploads/2018/06/ASCO-2018-breast-cancer-TNBC-MBC-ABC-ASCO18-PHEREXA-D-CARE-ABCSG-18-ASTRRA-TEXT-SOFT-MONARCH-2-MONALEESA-3-SANDPIPER-BOLERO-6-TOPACIO-KEYNOTE-162-TONIC-TOPACIO-GeparNeuvo.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-06-19 09:02:512018-06-19 23:57:08ASCO 2018 Breast Cancer: The ASCO18 breast cancer track summarised
      Ribociclib FDA label updated to include pre- and perimenopausal women
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      Bevacizumab in combination with carboplatin and paclitaxel FDA approved for several types of gynaecological cancers

      https://medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-06-14 22:56:042018-07-30 10:40:22Bevacizumab in combination with carboplatin and paclitaxel FDA approved for several types of gynaecological cancers
      Ribociclib FDA label updated to include pre- and perimenopausal women
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      FDA approved pembrolizumab for 3rd-line PMBCL in adult and pediatric patients

      https://medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-06-14 22:42:142018-07-30 10:40:10FDA approved pembrolizumab for 3rd-line PMBCL in adult and pediatric patients
      Ribociclib FDA label updated to include pre- and perimenopausal women
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      FDA approved pembrolizumab for chemotherapy-refractory r/m cervical cancer with PD-L1 CPS ≥1 

      https://medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-06-13 21:59:012018-07-30 10:39:54FDA approved pembrolizumab for chemotherapy-refractory r/m cervical cancer with PD-L1 CPS ≥1 
      ASCO18 ASCO 2018 HCC hepatocellular carcinoma liver cancer pembrolizumab KEYTRUDA atezolizumab TECENTRIQ PD-1 PD-L1 immunecheckpoint immunotherapy ramucirumab cabozantinib KEYNOTE-224 SCRUM-Japan GI-SCREEN CELESTIAL REACH-2
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      ASCO 2018 HCC: The ASCO18 hepatocellular cancer track summarised

      https://medi-paper.com/wp-content/uploads/2018/06/ASCO18-ASCO-2018-HCC-hepatocellular-carcinoma-liver-cancer-pembrolizumab-KEYTRUDA-atezolizumab-TECENTRIQ-PD-1-PD-L1-immunecheckpoint-immunotherapy-ramucirumab-cabozantinib-KEYNOTE-224-SCRUM-Japan-GI-SCREEN-CELESTIAL-REACH-2.jpg 1000 1500 Anne John Michael https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Anne John Michael2018-06-10 11:59:542018-08-23 10:33:26ASCO 2018 HCC: The ASCO18 hepatocellular cancer track summarised
      Ribociclib FDA label updated to include pre- and perimenopausal women
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      FDA approves venetoclax in 2nd-line for patients with CLL or SLL

      https://medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-06-09 11:25:082018-09-25 17:51:30FDA approves venetoclax in 2nd-line for patients with CLL or SLL
      Ribociclib FDA label updated to include pre- and perimenopausal women
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      FDA approved biosimilar pegfilgrastim to decrease the chance of febrile neutropenia in patients with non-myeloid cancers on myelosuppressive chemotherapy

      https://medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-06-06 16:07:462018-08-11 23:55:46FDA approved biosimilar pegfilgrastim to decrease the chance of febrile neutropenia in patients with non-myeloid cancers on myelosuppressive chemotherapy
      IMPower150 Reck Socinski ELCC AACR 2018 firstline atezolizumab bevacizumab chemotherapy non-squamous nsclc
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      AACR 2018: first-line atezolizumab, bevacizumab plus chemotherapy active in non-squamous NSCLC

      https://medi-paper.com/wp-content/uploads/2018/05/IMPower150-Reck-Socinski-ELCC-AACR-2018-firstline-atezolizumab-bevacizumab-chemotherapy-non-squamous-nsclc.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-05-10 16:19:462018-05-24 09:31:31AACR 2018: first-line atezolizumab, bevacizumab plus chemotherapy active in non-squamous NSCLC
      US FDA approved CAR-t cell BiTE DAR-T cell CD19 Immunotherapies blinatumomab axicabtagene ciloleucel tisagenlecleucel
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      US FDA approved CAR-T cell and BiTE immunotherapy – Updated 2-May-2018

      https://medi-paper.com/wp-content/uploads/2018/04/US-FDA-approved-CAR-t-cell-BiTE-DAR-T-cell-CD19-Immunotherapies-blinatumomab-axicabtagene-ciloleucel-tisagenlecleucel.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-05-02 10:00:352018-05-24 09:36:21US FDA approved CAR-T cell and BiTE immunotherapy – Updated 2-May-2018
      Ribociclib FDA label updated to include pre- and perimenopausal women
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      Adjuvant dabrafenib plus trametinib FDA approved for BRAF V600E or V600K melanoma

      https://medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-04-30 13:35:562018-07-30 11:42:21Adjuvant dabrafenib plus trametinib FDA approved for BRAF V600E or V600K melanoma
      AACR 2018 First-line Nivolumab-Ipilimumab in TMB-high NSCLC front-line immunotherapy for non-small cell lung cancer tumour-mutation burden CheckMate 227 NCT02477826
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      Nivolumab-Ipilimumab Combination: A New Option for TMB-High NSCLC (CheckMate 227)

      https://medi-paper.com/wp-content/uploads/2018/04/First-line-Nivolumab-Ipilimumab-in-TMB-high-NSCLC-front-line-immunotherapy-for-non-small-cell-lung-cancer-CheckMate-227-NCT02477826.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-04-21 10:30:432018-05-24 09:37:03Nivolumab-Ipilimumab Combination: A New Option for TMB-High NSCLC (CheckMate 227)
      Ribociclib FDA label updated to include pre- and perimenopausal women
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      FDA approved osimertinib for the 1st-line treatment of patients with EGFR exon 19 deletions or exon 21 L858R mutations positive metastatic non-small cell lung cancer (NSCLC)

      https://medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-04-19 13:36:062018-07-30 11:15:04FDA approved osimertinib for the 1st-line treatment of patients with EGFR exon 19 deletions or exon 21 L858R mutations positive metastatic non-small cell lung cancer (NSCLC)
      Ribociclib FDA label updated to include pre- and perimenopausal women
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      Frontline nivolumab plus ipilimumab approved for intermediate or poor risk advanced RCC

      https://medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-04-16 13:59:012018-07-30 11:50:31Frontline nivolumab plus ipilimumab approved for intermediate or poor risk advanced RCC
      Keynote-042 Keynote-024 pembrolizumab nsclc keytruda nsclc non-squamous squamous PD-L1 expression 1% 20% 50% Tony Mok MD NCT02220894 Pembrolizumab effective in frontline NSCLC with low PD-L1 expression
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      Pembrolizumab effective in frontline NSCLC with low PD-L1 expression

      https://medi-paper.com/wp-content/uploads/2018/04/Keynote-042-Keynote-024-pembrolizumab-nsclc-keytruda-nsclc-non-squamous-squamous-PD-L1-expression-1-20-50-Tony-Mok-MD-NCT02220894-Pembrolizumab-effective-in-frontline-NSCLC-with-low-PD-L1-expression.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-04-10 20:15:112018-05-24 09:37:32Pembrolizumab effective in frontline NSCLC with low PD-L1 expression
      Ribociclib FDA label updated to include pre- and perimenopausal women
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      Everolimus suspension approved in TSC-associated partial-onset seizures

      https://medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-04-10 14:07:302018-07-30 14:22:09Everolimus suspension approved in TSC-associated partial-onset seizures
      Herbert Loong on irAEs Immunotherapy (I-O) and New Onset Diabetes or immune-mediated diabetes
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      I-O in Special Populations: Diabetes and Concomitant Steroids

      https://medi-paper.com/wp-content/uploads/2018/02/Herbert-Loong-on-irAEs-Immunotherapy-I-O-and-New-Onset-Diabetes-or-immune-mediated-diabetes.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-04-06 09:00:412018-08-11 23:56:01I-O in Special Populations: Diabetes and Concomitant Steroids
      Crizotinib beneficial for East-Asian NSCLC-patients with ROS1 alterations crizotinib asian crizotinib ros1 crizotinib asian nsclc patients crizotinib asian non-small cell lung cancer patients
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      Crizotinib beneficial for East-Asian NSCLC patients with ROS1 alterations

      https://medi-paper.com/wp-content/uploads/2018/04/Crizotinib-beneficial-for-East-Asian-NSCLC-patients-with-ROS1-alterations-crizotinib-asian-crizotinib-ros1-crizotinib-asian-nsclc-patients-crizotinib-asian-non-small-cell-lung-cancer-patients-e1522913753323.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-04-04 16:00:112018-04-19 13:57:57Crizotinib beneficial for East-Asian NSCLC patients with ROS1 alterations
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      Death due to cancer on the decline for most tumours in Europe

      https://medi-paper.com/wp-content/uploads/2018/03/1522336566_Oncology-Breast-CNS-Chemotherapy-Endocrine-GI-GU-Geriatric-Gynecologic-GYN-OB-Head-and-Neck-Haematology-Immunotherapy-Lung-Melanoma-Skin-NET-Paediatric-Pathology-Sarcoma-Surgery-Targeted-Therapy-Translational-03.jpg 277 450 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-03-31 11:03:502018-08-10 11:57:59Death due to cancer on the decline for most tumours in Europe
      immunotherapy I-O immunooncology nivolumab npc opdivo nasopharyngeal carcinoma brigette ma CUHK phase II nci-9742 study JCO journal of clinical oncology
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      Nivolumab for NPC: immunotherapy active in nasopharyngeal carcinoma (NCI-9742)

      https://medi-paper.com/wp-content/uploads/2018/03/nivolumab-npc-opdivo-nasopharyngeal-carcinoma-brigette-ma-CUHK-phase-II-nci-9742-study-JCO-journal-of-clinical-oncology.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-03-31 09:20:312018-05-24 09:38:41Nivolumab for NPC: immunotherapy active in nasopharyngeal carcinoma (NCI-9742)