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CARDIOVASCULAR DISEASE

Baloxavir marboxil recommended as post-exposure prophylaxis to influenza by EMA

Medical writer: Kirsty LEE | Last updated: 11th December 2020 | In: Gastrointestinal Cancer, Lung Cancer, Oncology, Targeted Therapies

Article Keywords

AMG 510, CRC, KRAS, KRAS G12C, NSCLC, RAS, solid tumours, sotorasib

Seasonal influenza is common between January to March, and July to August in Hong Kong.1Centre for Health Protection, Department of Health – Seasonal Influenza. Available at: https://www.chp.gov.hk/en/healthtopics/content/24/29.html (Accessed 9 December 2020). Baloxavir marboxil is the first influenza antiviral with a novel mechanism of action to be approved in almost two decades, and was registered for use in Hong Kong in February 2019.2,3O’Hanlon R et al. Curr Opin Virol. 2019;35:14-18.
Drug Office, Department of Health. Available at: https://www.drugoffice.gov.hk/eps/drug/productDetail/en/consumer/122421 (Accessed 9 December 2020).
 It is approved for the treatment of acute uncomplicated influenza in patients 12 years of age and older, who have been symptomatic for no more than 48 hours.2O’Hanlon R et al. Curr Opin Virol. 2019;35:14-18 It was recently approved as post-exposure prophylaxis for influenza by both the US FDA and EMA, based on the results of the BLOCKSTONE study.4-6 Roche announces FDA approval of Xofluza for the prevention of influenza following contact with an infected person. Roche. Available at: https://www.roche.com/media/releases/med-cor-2020-11-24.htm (Accessed 9 December 2020).
EMA Panel Backs Xofluza for Influenza, Post-Exposure Prophylaxis. Medscape. Available at: https://www.medscape.com/viewarticle/941059 (Accessed 9 December 2020).
Ikematsu H et al. N Engl J Med. Published online July 8, 2020.

The multicentre, double-blind, randomised, placebo-controlled BLOCKSTONE trial evaluated the postexposure prophylactic efficacy of baloxavir marboxil in household contacts of index patients with confirmed influenza during the 2018-2019 flu season in Japan.6Ikematsu H et al. N Engl J Med. Published online July 8, 2020. Index patients were defined as the first documented case of influenza in a household, on basis of a positive rapid influenza diagnostic test.6Ikematsu H et al. N Engl J Med. Published online July 8, 2020. In total 752 participants were classified as asymptomatic close contacts who had lived in the same household as the index patient or at least 48 hours before enrolment and were randomised 1:1 to receive either baloxavir or matching placebo.6Ikematsu H et al. N Engl J Med. Published online July 8, 2020. The primary efficacy endpoint was laboratory-confirmed clinical influenza, and key secondary endpoints included RT-PCR confirmed illness, and RT-PCR confirmed influenza virus infection regardless of fever and symptoms.6Ikematsu H et al. N Engl J Med. Published online July 8, 2020. Risk ratios were adjusted for randomization factors (time from onset of illness, type of antiviral treatment of index patient, and age of the participant [continuous variable]).6Ikematsu H et al. N Engl J Med. Published online July 8, 2020.

The majority of participants (72.5%) received baloxavir or placebo within 24 hours after onset of illness in the index patient.6Ikematsu H et al. N Engl J Med. Published online July 8, 2020. The primary endpoint of laboratory-confirmed clinical influenza was met by 1.9% and 13.6% of participants receiving baloxavir and placebo, respectively (adjusted risk ratio [aRR]=0.14; 95% CI: 0.06-0.30; p<0.001).6Ikematsu H et al. N Engl J Med. Published online July 8, 2020. Baloxavir prophylaxis led to a lower percentage of patients with RT-PCR confirmed illness than placebo (aRR=0.24; 95% CI: 0.15-0.38), and a lower percentage of patients with RT-PCR-confirmed influenza virus infection regardless of fever and symptoms (aRR=0.43; 95% CI: 0.32-0.58).6Ikematsu H et al. N Engl J Med. Published online July 8, 2020.

Adverse events (AEs) were reported in 22.2% of participants who received baloxavir, and 20.5% of those who received placebo.6Ikematsu H et al. N Engl J Med. Published online July 8, 2020. The most common adverse events were headache, haematuria, pharyngitis, and increases in alanine aminotransferase levels.6Ikematsu H et al. N Engl J Med. Published online July 8, 2020.

Reference

  1. Centre for Health Protection, Department of Health – Seasonal Influenza. Available at: https://www.chp.gov.hk/en/healthtopics/content/24/29.html (Accessed 9 December 2020).
  2. O’Hanlon R et al. Curr Opin Virol. 2019;35:14-18.
  3. Drug Office, Department of Health. Available at: https://www.drugoffice.gov.hk/eps/drug/productDetail/en/consumer/122421 (Accessed 9 December 2020).
  4. Roche announces FDA approval of Xofluza for the prevention of influenza following contact with an infected person. Roche. Available at: https://www.roche.com/media/releases/med-cor-2020-11-24.htm (Accessed 9 December 2020).
  5. EMA Panel Backs Xofluza for Influenza, Post-Exposure Prophylaxis. Medscape. Available at: https://www.medscape.com/viewarticle/941059 (Accessed 9 December 2020).
  6. Ikematsu H et al. N Engl J Med. Published online July 8, 2020.

Disclaimer

This article is not medical advice. Patients should seek personal assessment by a licenced specialist. Physicians are recommended to read the full publication(s) as cited in the article before making medical decisions. This article does not supersede nor replace the published article(s).

© Copyright 2020 MediPaper Medical Communications Ltd. – Baloxavir marboxil recommended as post-exposure prophylaxis to influenza by EMA

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ASCO 2019 Breast Cancer: The ASCO19 breast cancer track summarised

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Venetoclax FDA approved for CLL and SLL

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FDA approves avelumab plus axitinib for renal cell carcinoma

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Ramucirumab FDA approved for hepatocellular carcinoma

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T-DM1 FDA approved for early breast cancer

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Ivosidenib FDA-approved as first-line treatment for AML patients with IDH1 mutation

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Can a novel, temporary, and fully resorbable surgical implant improve the outcome of common hockey and soccer injuries?
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Can a novel, temporary, and fully resorbable surgical implant improve the outcome of common hockey and soccer injuries?

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Pembrolizumab plus axitinib FDA approved for the first-line treatment of advanced renal cell carcinoma patients

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KEYNOTE-158 pembrolizumab in previously treated advanced cervical cancer
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KEYNOTE-158: pembrolizumab in previously treated advanced cervical cancer

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Atezolizumab with or without cobimetinib vs regorafenib for previously treated metastatic colorectal cancer IMblaze370
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Atezolizumab +/- cobimetinib vs regorafenib for previously treated metastatic colorectal cancer (IMblaze370)

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Palbociclib approved for the treatment of male breast cancer 

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Erdafitinib FDA approved for the treatment of metastatic urothelial carcinoma

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Atezolizumab FDA approved for extensive-stage small cell lung cancer (SCLC)

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Atezolizumab FDA approved for PD-L1 positive unresectable triple-negative breast cancer

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Immunoncology I-O drugs and immunotherapy for renal cancer RCC
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Combinations: upcoming treatment strategies in metastatic renal cell carcinoma

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Trifluridine/tipiracil combination FDA approved for metastatic gastric or GEJ adenocarcinoma

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Pembrolizumab FDA approved for adjuvant treatment of melanoma

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Trastuzumab-biosimilar Ontruzant® FDA approved in several indications

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Cabozantinib FDA approved in HCC patients failing sorafenib

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Erasmus University MC investigating a new surgical matrix to reduce post-operative complications
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Erasmus University MC investigating a new surgical matrix to reduce post-operative complications

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Keytruda® FDA approved for recurrent and metastatic Merkel cell carcinoma

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Calaspargase pegol-mknl (Asparlas®) FDA approved in paediatric and young adult acute lymphoblastic leukaemia (ALL) patients

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Elzonris™ FDA approved for blastic plasmacytoid dendritic cell neoplasm (BPDCN)

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Olaparib (Lynparza) FDA approved as maintenance for BRCAm ovarian cancer

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Trastuzumab-biosimilar Herzuma® FDA approved in HER2+ breast cancer

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Frontline atezolizumab plus bevacizumab and chemotherapy FDA approved for metastatic non-squamous NSCLC

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MURANO: off-drug progression-free survival after 2 years venetoclax plus 6 cycles Rituximab
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MURANO: off-drug progression-free survival after 2 years venetoclax plus 6 cycles Rituximab

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TIGR®Matrix shows promising results when used for incisional hernia prevention in septic patients undergoing laparoscopy
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TIGR®Matrix shows promising results when used for incisional hernia prevention in septic patients undergoing laparoscopy

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Gilteritinib (Xospata®) FDA approved for relapsed or refractory AML harbouring FLT3 mutations

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TKR inhibitor larotrectinib (Vitrakvi®) FDA approved for cancers with NTRK gene fusion

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FDA Approves Truxima as Biosimilar to Rituxan

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Venetoclax plus azacitidine, decitabine, or low-dose cytarabine FDA approved in elderly AML patients

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Glasdegib plus low-dose cytarabine (LDAC) approved in elderly AML patients

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Robert Lewandowski Y90 TARE TheraSphere The Emerging Role of Yttrium90 in Primary and Metastatic Liver Cancer hepatocellular carcinoma hcc
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The Emerging Role of Yttrium-90 in Primary and Metastatic Liver Cancer

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Emapalumab FDA approved in adult and paediatric patients with primary hemophagocytic lymphohistiocytosis

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Brentuximab vedotin (Adcetris®) plus chemotherapy approved for several CD30 expressing lymphomas

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Fully resorbable synthetic matrix offers improved safety for breast cancer patients undergoing immediate breast reconstruction
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Fully resorbable synthetic matrix offers improved safety for breast cancer patients undergoing immediate breast reconstruction

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Pembrolizumab FDA approved in hepatocellular carcinoma patients pretreated with sorafenib

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Lorlatinib FDA approved for metastatic ALK-positive NSCLC

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ESMO 2018 HCC ESMO18 Liver Cancer ESMO2018 hepatocellular carcinoma hepatobiliary cholangiocarcinoma BTC
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ESMO 2018 HCC: The ESMO18 hepatobiliary cancer track summarised

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Pembrolizumab plus chemotherapy approved for metastatic squamous NSCLC

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Dr Joanne Chiu HKU management irAE hepatitis manage immune-mediated hepatitis immunotherapy I-O immunooncology immune-induced hepatitis
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Management of Immune-Mediated Hepatitis: a Case Report

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PARPi talazoparib FDA approved for deleterious gBRCAm HER2‑negative breast cancer

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innovent biologics anti-pd1 sintilimab plus biosimilar bevacizumab receive ind status by china nmpa
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Anti-PD1 sintilimab plus biosimilar bevacizumab receive IND-status by China NMPA

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IMpower133 first-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer
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IMpower133: first-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer

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Pembrolizumab plus chemotherapy effective in squamous NSCLC
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Pembrolizumab plus chemotherapy effective in squamous NSCLC

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Ipilimumab plus nivolumab for persistent or recurrent ovarian cancer
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Ipilimumab plus nivolumab for persistent or recurrent ovarian cancer

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Brigatinib prolongs PFS compared to crizotinib in ALK-Positive NSCLC
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Brigatinib prolongs PFS compared to crizotinib in ALK-Positive NSCLC

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CAR-T axicabtagene ciloleucel granted Orphan Drug Designation for B-Cell Lymphoma by the Japan MHLW
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CAR-T axicabtagene ciloleucel granted Orphan Drug designation for B-Cell Lymphoma by the Japan MHLW

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PD-1 mAB cemiplimab FDA approved for locally advanced and metastatic cutaneous squamous cell carcinoma (CSCC)

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JAVELIN Lung 200 avelumab vs docetaxel in patients with pretreated advanced non-small cell lung cancer NSCLC
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JAVELIN Lung 200: avelumab vs docetaxel for pretreated NSCLC

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Dacomitinib FDA approved for the first-line treatment of metastatic EGFR-mutated NSCLC

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Duvelisib FDA approved for adult patients with R/R CLL or SLL

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Duvelisib FDA approved for adult patients with R/R follicular lymphoma

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Front-line atezolizumab plus chemotherapy improves PFS in NSCLC
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Frontline atezolizumab plus chemotherapy improves PFS in NSCLC

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First-line osimertinib vs EGFR-TKI in Asian patients with advanced NSCLC
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First-line osimertinib vs EGFR-TKI in Asian patients with advanced NSCLC

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Early breast cancer treatment in China remains conservative
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Early breast cancer treatment in China remains conservative

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immuno-oncology I-O treatment for the irAE Rash
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ImmunoOncology: Dr Oscar Chan on the treatment of irAE rash

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Prof Stefan Kasper on I-O in EXTREME-ineligible Head and Neck Cancer I-O in SCCHN with focus on EXTREME-ineligible Patients and the future directions of combination immunotherapy
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Prof Stefan Kasper on I-O in EXTREME-ineligible SCCHN

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Camrelizumab anti-PD-1 with or without Chemotherapy for NPC
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Camrelizumab anti-PD-1 with or without chemotherapy for NPC

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Moxetumomab pasudotox-tdfk FDA approved for hairy cell leukaemia

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Adrian TSE HKIOC irAE pneumonitis lung immunotherapy-induced pneumonitis I-O Immuno-Oncology cannonball metastases cancer
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I-O in Special Populations: the Treatment of Immunotherapy-Induced Pneumonitis

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Venetoclax FDA label updated to include Minimal Residual Disease negativity data

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Quizartinib Receives Orphan Drug Designation for FLT3-Mutated AML in Japan
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Quizartinib receives Orphan Drug designation for FLT3-mutated AML in Japan

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Lung Cancer Capmatinib plus gefitinib promising in MET-dysregulated NSCLC MediPaper Medical Communications Medical Writer Hong Kong 醫學寫作 醫學作家香港
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Capmatinib plus gefitinib promising in MET-dysregulated NSCLC

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CAR-TCR Summit 2018 Preliminary first-in-human data with CAR-Claudin18.2-T in gastric and pancreatic cancer
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CAR-TCR Summit 2018: Preliminary first-in-human data with CAR-Claudin18.2-T in gastric and pancreatic cancer

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DRIVER connects cancer patients in China and the United States to the best care
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DRIVER connects cancer patients in China and the United States to the best care

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Blood-based TMB-assay predicts response to atezolizumab in NSCLC patients
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Plasma TMB predicts response to atezolizumab in NSCLC patients

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First-in-Class Oncology Vaccine BIL06v Starts Phase 1 Evaluation
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First-in-Class Oncology Vaccine BIL06v Starts Phase 1 Evaluation

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Nivolumab FDA approved for patients with metastatic small cell lung cancer (SCLC)
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Pembrolizumab and atezolizumab USPIs updated by FDA

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Nivolumab FDA approved for patients with metastatic small cell lung cancer (SCLC)
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Nivolumab FDA approved for patients with metastatic small cell lung cancer (SCLC)

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Pembrolizumab plus pemetrexed-platinum approved for use in the 1st-line treatment of metastatic non-squamous NSCLC
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Pembrolizumab plus pemetrexed-platinum FDA approved for first-line treatment of metastatic non-squamous NSCLC

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Talazoparib in advanced breast cancer patients with a germline BRCA1:2 mutation
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Talazoparib in advanced breast cancer patients with a germline BRCA1/2 mutation

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CheckMate 032 Nivolumab ipilimumab metastatic esophagogastric cancer
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CheckMate 032: Nivolumab +/- ipilimumab for metastatic esophagogastric cancer

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Pembrolizumab plus pemetrexed-platinum approved for use in the 1st-line treatment of metastatic non-squamous NSCLC
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Lenvatinib FDA approved for 1st-line treatment of HCC

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Pan-EGFR TKI pirotinib has commenced into Phase II clinical testing in China
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Pan-EGFR TKI pirotinib has commenced into Phase II clinical testing in China

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FDA approved lusutrombopag (Mulpleta, Shionogi Inc.) for thrombocytopenia in adults with chronic liver disease who are scheduled to undergo a medical or dental procedure. More Information.  July 31, 2018.
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FDA approved mogamulizumab for adult patients with relapsed or refractory CTCL

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FDA approved lusutrombopag (Mulpleta, Shionogi Inc.) for thrombocytopenia in adults with chronic liver disease who are scheduled to undergo a medical or dental procedure. More Information.  July 31, 2018.
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Lusutrombopag FDA approved for thrombocytopenia in adult chronic liver disease patients

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Ribociclib FDA label updated to include pre- and perimenopausal women
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Iobenguane I-131 FDA approved for rare adrenal neuroendocrine tumours

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T790M osimertinib nsclc brain metastasis CNS metastases Osimertinib in patients With T790M-Positive Advanced Non-Small-Cell Lung Cancer and brain metastases AURA3
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Osimertinib in patients with T790M-positive advanced non-small cell lung cancer and brain metastases (AURA3)

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Anti-PD1 with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma
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Anti-PD1 with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma

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Ribociclib FDA label updated to include pre- and perimenopausal women
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Ivosidenib FDA approved for relapsed or refractory acute myeloid leukemia

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FDA approved enzalutamide (XTANDI, Astellas Pharma US, Inc.), for patients with castration-resistant prostate cancer (CRPC). More Information.  July 13, 2018
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Filgrastim-aafi FDA approved as Filgrastim Biosimilar

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Ribociclib FDA label updated to include pre- and perimenopausal women
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Ribociclib FDA label updated to include pre- and perimenopausal women

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FDA approved enzalutamide (XTANDI, Astellas Pharma US, Inc.), for patients with castration-resistant prostate cancer (CRPC). More Information.  July 13, 2018
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Enzalutamide FDA approved for castration-resistant prostate cancer (CRPC)

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EBV pembrolizumab gastric cancer - MSI-H pembrolizumab gastric cancer - CPS pembrolizumab gastric cancer - MSI, EBV, CPS predict pembrolizumab outcome in gastric cancer
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EBV, MSI, and CPS predict pembrolizumab outcome in gastric cancer

https://medi-paper.com/wp-content/uploads/2018/08/EBV-pembrolizumab-gastric-cancer-MSI-H-pembrolizumab-gastric-cancer-CPS-pembrolizumab-gastric-cancer-MSI-EBV-CPS-predict-pembrolizumab-outcome-in-gastric-cancer.jpg 1000 1500 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-16 14:03:432018-08-31 08:15:52EBV, MSI, and CPS predict pembrolizumab outcome in gastric cancer
Ribociclib FDA label updated to include pre- and perimenopausal women
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Ipilimumab plus nivolumab FDA approved for MSI-H and dMMR pre-treated mCRC

https://medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-11 20:52:132018-07-30 10:41:58Ipilimumab plus nivolumab FDA approved for MSI-H and dMMR pre-treated mCRC
Ribociclib FDA label updated to include pre- and perimenopausal women
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Combination encorafenib plus binimetinib for unresectable/metastatic BRAF V600E or V600K-positive melanoma FDA approved

https://medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-02 22:14:052018-07-30 10:41:23Combination encorafenib plus binimetinib for unresectable/metastatic BRAF V600E or V600K-positive melanoma FDA approved
ASCO 2018 nsclc immunotherapy ASCO18 lung cancer pembrolizumab avelumab nivolumab duravalumab ipilimumab osimertinib dacomitinib lorlatinib crizotinib alectinib keytruda KEYNOTE CheckMate JAVELIN IMpower
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ASCO 2018 NSCLC: The ASCO18 Lung Cancer Track Summarised

https://medi-paper.com/wp-content/uploads/2018/06/ASCO-2018-nsclc-immunotherapy-ASCO18-lung-cancer-pembrolizumab-avelumab-nivolumab-duravalumab-ipilimumab-osimertinib-dacomitinib-lorlatinib-crizotinib-alectinib-keytruda-KEYNOTE-CheckMate-JAVELIN-IMpower.jpg 1000 1500 Anne John Michael https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Anne John Michael2018-06-25 18:22:252018-08-21 11:43:54ASCO 2018 NSCLC: The ASCO18 Lung Cancer Track Summarised
FDA  has limited the use of Tecentriq and Keytruda for patients with locally advanced or metastatic urothelial cancer who are not eligible for cisplatin-containing therapy.  More Information.  June 19, 2018
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FDA limits use of atezolizumab and pembrolizumab in urothelial carcinoma

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ASCO 2018 breast cancer TNBC MBC ABC ASCO18 PHEREXA D-CARE ABCSG-18 ASTRRA TEXT SOFT MONARCH-2 MONALEESA-3 SANDPIPER BOLERO-6 TOPACIO KEYNOTE-162 TONIC TOPACIO GeparNeuvo
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ASCO 2018 Breast Cancer: The ASCO18 breast cancer track summarised

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Ribociclib FDA label updated to include pre- and perimenopausal women
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Bevacizumab in combination with carboplatin and paclitaxel FDA approved for several types of gynaecological cancers

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FDA approved pembrolizumab for 3rd-line PMBCL in adult and pediatric patients

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FDA approved pembrolizumab for chemotherapy-refractory r/m cervical cancer with PD-L1 CPS ≥1 

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ASCO18 ASCO 2018 HCC hepatocellular carcinoma liver cancer pembrolizumab KEYTRUDA atezolizumab TECENTRIQ PD-1 PD-L1 immunecheckpoint immunotherapy ramucirumab cabozantinib KEYNOTE-224 SCRUM-Japan GI-SCREEN CELESTIAL REACH-2
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ASCO 2018 HCC: The ASCO18 hepatocellular cancer track summarised

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FDA approves venetoclax in 2nd-line for patients with CLL or SLL

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FDA approved biosimilar pegfilgrastim to decrease the chance of febrile neutropenia in patients with non-myeloid cancers on myelosuppressive chemotherapy

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IMPower150 Reck Socinski ELCC AACR 2018 firstline atezolizumab bevacizumab chemotherapy non-squamous nsclc
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AACR 2018: first-line atezolizumab, bevacizumab plus chemotherapy active in non-squamous NSCLC

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US FDA approved CAR-t cell BiTE DAR-T cell CD19 Immunotherapies blinatumomab axicabtagene ciloleucel tisagenlecleucel
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US FDA approved CAR-T cell and BiTE immunotherapy – Updated 2-May-2018

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Ribociclib FDA label updated to include pre- and perimenopausal women
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Adjuvant dabrafenib plus trametinib FDA approved for BRAF V600E or V600K melanoma

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AACR 2018 First-line Nivolumab-Ipilimumab in TMB-high NSCLC front-line immunotherapy for non-small cell lung cancer tumour-mutation burden CheckMate 227 NCT02477826
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Nivolumab-Ipilimumab Combination: A New Option for TMB-High NSCLC (CheckMate 227)

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Ribociclib FDA label updated to include pre- and perimenopausal women
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FDA approved osimertinib for the 1st-line treatment of patients with EGFR exon 19 deletions or exon 21 L858R mutations positive metastatic non-small cell lung cancer (NSCLC)

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NCT02578680 Keynote189 AACR 2018 pembrolizumab chemotherapy nsclc NEJM Leena Gandhi
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Frontline Combination of Pembrolizumab and Chemotherapy: A New Standard of Care for Non-squamous NSCLC

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Ribociclib FDA label updated to include pre- and perimenopausal women
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Frontline nivolumab plus ipilimumab approved for intermediate or poor risk advanced RCC

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Keynote-042 Keynote-024 pembrolizumab nsclc keytruda nsclc non-squamous squamous PD-L1 expression 1% 20% 50% Tony Mok MD NCT02220894 Pembrolizumab effective in frontline NSCLC with low PD-L1 expression
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Pembrolizumab effective in frontline NSCLC with low PD-L1 expression

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Ribociclib FDA label updated to include pre- and perimenopausal women
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Everolimus suspension approved in TSC-associated partial-onset seizures

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Herbert Loong on irAEs Immunotherapy (I-O) and New Onset Diabetes or immune-mediated diabetes
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I-O in Special Populations: Diabetes and Concomitant Steroids

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Crizotinib beneficial for East-Asian NSCLC-patients with ROS1 alterations crizotinib asian crizotinib ros1 crizotinib asian nsclc patients crizotinib asian non-small cell lung cancer patients
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Crizotinib beneficial for East-Asian NSCLC patients with ROS1 alterations

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Death due to cancer on the decline for most tumours in Europe

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immunotherapy I-O immunooncology nivolumab npc opdivo nasopharyngeal carcinoma brigette ma CUHK phase II nci-9742 study JCO journal of clinical oncology
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Nivolumab for NPC: immunotherapy active in nasopharyngeal carcinoma (NCI-9742)

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FDA granted accelerated approval to blinatumomab for the treatment of adult and paediatric patients with B-cell precursor ALL in first or second complete remission with MRD ≥0.1%

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Making sense of immunotherapy in NSCLC
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Making sense of 1st-line immunotherapy in non-small cell lung cancer (NSCLC)

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manuela schmidinger sutent sunitinib ae management manuela schmidinger manuela schmidinger sutent sunitinib side-effect management sutent sunitinib toxicity management Sutent Sunitinib AE management toxicity management side-effect management sorafenib pazopanib axitinib regorafenib vandetanib cabozantinib lenvatinib bevacizumab VEGFR VEGF renal cell carcinoma RCC kidney cancer renal cell cancer schmidinger
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Achieving Long-Term Survival in the First-Line Treatment of Metastatic Renal Cell Carcinoma; A Balancing Act of Efficacy and Side-Effects

https://medi-paper.com/wp-content/uploads/2017/11/image.png 852 1471 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2017-11-29 22:12:232018-04-19 10:46:51Achieving Long-Term Survival in the First-Line Treatment of Metastatic Renal Cell Carcinoma; A Balancing Act of Efficacy and Side-Effects