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BREAST CANCER

Breast cancer update January 2021

By: Kirsty LEE | Last updated: 1st February 2021 | In: Breast Cancer, Chemotherapy, Endocrine Therapy, Oncology, Radiology, Targeted Therapies, Translational Research

Article Keywords

AACR, aromatase inhibitor, atezolizumab, BRCA, carboplatin, CEF-T, circulating tumour cell, CTC, cyclophosphamide, docetaxel, endocrine therapy, epirubicin, ER-positive, ERBB2, eribulin, fluorouracil, gimeracil, HER2, HER2-negative, HER2-positive, HR-positive, indoximod, JAMA, JCO, Ki67, Lancet Oncology, margetuximab, NEJM, oteracil, paclitaxel, palbociclib, pCR, pembrolizumab, pertuzumab, POAI, S-1, SABCS, tegafur, TNBC, trastuzumab, veliparib

With the San Antonio Breast Cancer Conference (SABCS) 2020 by AACR just completed, several new and clinical relevant phase 2 and phase 3 have been published in the Journal of the American Medical Association, Clinical Cancer Research, New England Journal of Medicine, Journal of Clinical Oncology, and Lancet Oncology.

[‘mediPr] provides you with an overview.

Efficacy of Margetuximab vs Trastuzumab in Patients With Pretreated ERBB2-Positive Advanced Breast Cancer: A Phase 3 Randomised Clinical Trial

Hope S Rugo et al.

SOPHIA trial by Rugo et al. found statistically significant improved PFS with margetuximab plus chemotherapy compared with trastuzumab plus chemotherapy in ERBB2-positive ABC after progression on 2 or more prior anti-ERBB2 therapies. The trial was a phase 3 randomised open-label trial that enrolled 536 patients, with sequential primary endpoints of PFS and OS.

NCT02492711      PMID: 33480963     DOI: 10.1001/jamaoncol.2020.7932

Palbociclib with adjuvant endocrine therapy in early breast cancer (PALLAS): interim analysis of a multicentre, open-label, randomised, phase 3 study

Erica L Mayer et al.

PALLAS trial by Mayer et al. found adjuvant palbociclib for 2 years did not improve invasive DFS compared with adjuvant endocrine therapy alone in patients with stage II-III histologically confirmed HR+, HER2- breast cancer. The trial is an ongoing, multicentre, open-label, randomised phase 3 trial enrolling 5760 patients, with a primary endpoint of invasive DFS in the ITT population.

NCT02513394       PMID: 33460574        DOI: 10.1016/S1470-2045(20)30642-2

Adjuvant S-1 plus endocrine therapy for oestrogen receptor-positive, HER2-negative, primary breast cancer: a multicentre, open-label, randomised, controlled, phase 3 trial

Masakazu Toi et al.

Toi et al. conducted a multicentre, open-label, randomised, controlled phase 3 trial in patients with stage I to IIIB invasive breast cancer, comparing standard adjuvant endocrine therapy with or without 1 year of S-1. The S-1 group had significantly improved invasive DFS, suggesting the combination could be a potential treatment option for intermediate and high-risk ER+, HER2- patients.

PMID: 33387497       DOI: 10.1016/S1470-2045(20)30534-9

Fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection plus chemotherapy in HER2-positive early breast cancer (FeDeriCa): a randomised, open-label, multicentre, non-inferiority, phase 3 study

Antoinette R Tan et al.

FeDeriCa trial by Tan et al. found the fixed-dose combination of pertuzumab and trastuzumab as subcutaneous injection was non-inferior to intravenous administration in the neoadjuvant setting, in terms of cycle 7 pertuzumab serum trough concentrations. The trial was a randomised, open-label, multicentre non-inferiority phase 3 trial enrolling 252 patients to receive either intravenous pertuzumab and trastuzumab, or the subcutaneous fixed-dose combination of the two. Primary endpoint was non-inferiority of the cycle 7 pertuzumab serum trough concentration.

NCT03493854       PMID: 33357420       DOI: 10.1016/S1470-2045(20)30536-2

Long-term outcome and prognostic value of Ki67 after perioperative endocrine therapy in postmenopausal women with hormone-sensitive early breast cancer (POETIC): an open-label, multicentre, parallel-group, randomised, phase 3 trial

Ian Smith et al.

The POETIC trial by Smith et al. found POAI therapy did not improve treatment outcome but can be used to select appropriate adjuvant therapy based on Ki67. The trial was an open-label, multicentre, parallel-group, randomised phase 3 trial enrolling 4480 postmenopausal women to receive either POAI for 14 days preceding and following surgery, or no POAI. The primary endpoint was time to recurrence, and secondary endpoint was association between Ki67 and disease outcome.

NCT02338310       PMID: 33152284       PMC: PMC7606901       DOI: 10.1016/S1470-2045(20)30458-7

Internal mammary and medial supraclavicular lymph node chain irradiation in stage I-III breast cancer (EORTC 22922/10925): 15-year results of a randomised, phase 3 trial

Philip M Poortmans

The 15-year analysis of EORTC 22922/10925 by Poortmans et al. found IM-MS irradiation in stage I-III breast cancer led to significant reduction in breast cancer mortality and any breast cancer recurrence, but did not translate to improved OS. The trial was a randomised, phase 3 trial enrolling 4004 patients to receive either IM-MS irradiation or no IM-MS radiation, with a primary endpoint of overall survival.

NCT00002851       PMID: 33152277       DOI: 10.1016/S1470-2045(20)30472-1

Effect of Taxane Chemotherapy With or Without Indoximod in Metastatic Breast Cancer: A Randomised Clinical Trial

Veronica Mariotti et al.

A phase 2, double-blinded, placebo-controlled randomised trial by Mariotti et al. found the addition of indoximod to a taxane did not improve PFS compared with a taxane alone in ERBB2-negative MBC. The trial randomised 169 patients, with a primary endpoint of PFS and secondary endpoints of median OS, ORR, and safety.

NCT01792050       PMID: 33151286       PMC: PMC7645745       DOI: 10.1001/jamaoncol.2020.5572

Efficacy of Circulating Tumor Cell Count-Driven vs Clinician-Driven First-line Therapy Choice in Hormone Receptor-Positive, ERBB2-Negative Metastatic Breast Cancer: The STIC CTC Randomised Clinical Trial

François-Clément Bidard et al.

The STIC CTC trial by Bidard et al. found CTC count may be a reliable biomarker for choosing between chemotherapy and endocrine therapy as first-line treatment in HR+, ERBB2- MBC. The trial enrolled 755 patients randomised to either CTC arm where chemotherapy or endocrine therapy was chosen according to CTC count (chemotherapy if ≥5CTCs/7.5 mL; endocrine therapy if <5 CTCs/7.5 mL), or control arm, where treatment choice was investigator-chosen, with a primary endpoint of investigator-assessed PFS. NCT01710605       PMID: 33151266       PMC: PMC7645742       DOI: 10.1001/jamaoncol.2020.5660

Trastuzumab emtansine plus atezolizumab versus trastuzumab emtansine plus placebo in previously treated, HER2-positive advanced breast cancer (KATE2): a phase 2, multicentre, randomised, double-blind trial

Leisha A Emens et al.

KATE2 trial by Emens et al. found addition of atezolizumab to trastuzumab emtansine did not lead to clinical improvement in PFS and was associated with more adverse events. The trial was a randomised, double-blind, placebo-controlled phase 2 trial enrolling 202 patients with HER2+ ABC, with a primary endpoint of investigator-assessed PFS in the ITT population.

NCT02924883       PMID: 33002436       DOI: 10.1016/S1470-2045(20)30465-4

Effect of Eribulin With or Without Pembrolizumab on Progression-Free Survival for Patients With Hormone Receptor-Positive, ERBB2-Negative Metastatic Breast Cancer: A Randomised Clinical Trial

Sara M Tolaney et al.

A multicentre, randomised, phase 2 clinical trial by Tolaney et al. found the addition of pembrolizumab to eribulin did not improve PFS, OS, or ORR compared with eribulin alone in patients with HR+, ERBB2- MBC who had received 2 or more lines of hormonal therapy and 0-2 lines of chemotherapy. The trial enrolled 88 patients who were randomised 1:1, with a primary endpoint of PFS, and secondary endpoints of OS and ORR.

NCT03051659       PMID: 32880602       PMC: PMC7489368       DOI: 10.1001/jamaoncol.2020.3524

Veliparib with carboplatin and paclitaxel in BRCA-mutated advanced breast cancer (BROCADE3): a randomised, double-blind, placebo-controlled, phase 3 trial

Véronique Diéras et al.

BROCADE3 trial by Diéras et al. found the addition of veliparib to a platinum doublet resulted in significant and durable PFS improvements in ABC patients with germline BRCA mutations. The trial was a randomised, double-blind, placebo-controlled phase 3 trial enrolling 513 patients randomised 2:1 to carboplatin and paclitaxel combined with veliparib, or matching placebo. The primary endpoint was investigator-assessed PFS.

NCT02163694       PMID: 32861273       DOI: 10.1016/S1470-2045(20)30447-2

Effect of Adjuvant Paclitaxel and Carboplatin on Survival in Women With Triple-Negative Breast Cancer: A Phase 3 Randomised Clinical Trial

Ke-Da Yu et al.

PATTERN trial by Yu et al. found that paclitaxel plus carboplatin regimen as an alternative adjuvant chemotherapy choice was effective in patients with operable TNBC. The phase 3 randomised trial compared 6 cycles of paclitaxel plus carboplatin with the standard-dose regimen of 3 cycles of CEF-T in 647 patients, with a primary endpoint of DFS.

NCT01216111       PMID: 32789480       PMC: PMC7426881       DOI: 10.1001/jamaoncol.2020.2965

Association of Event-Free and Distant Recurrence-Free Survival With Individual-Level Pathologic Complete Response in Neoadjuvant Treatment of Stages 2 and 3 Breast Cancer: Three-Year Follow-up Analysis for the I-SPY2 Adaptively Randomised Clinical Trial

Douglas Yee et al.

Three-year follow up of the I-SPY2 trial by Yee et al. found achieving pCR after neoadjuvant therapy implies an 80% reduction in recurrence rate that is regardless of treatment regimen or subtype. The trial was a multicentre neoadjuvant platform phase 2 trial enrolling 950 patients who were randomised to one of several different investigational regimens or control therapy within molecular subtypes, to evaluate the association of pCR with EFS and distant recurrence-free survival.

NCT01042379       PMID: 32701140       PMC: PMC7378873       DOI: 10.1001/jamaoncol.2020.2535

Abbreviations:

ABC, advanced breast cancer; CEF-T, cyclophosphamide, epirubicin, fluorouracil, docetaxel; CTC, circulating tumour cell; DFS, disease-free survival; EFS, event-free survival; ER+, oestrogen receptor positive; ERBB2+ / HER2+, human epidermal growth factor receptor positive; ERBB2- / HER2-, human epidermal growth factor receptor negative; HR+, hormone receptor positive; IM-MS, internal mammary and medial supraclavicular; ITT, intention-to-treat; MBC, metastatic breast cancer; ORR, objective response rate; OS, overall survival; pCR, pathologic complete response; PFS, progression-free survival; POAI, preoperative and postoperative aromatase inhibitor; S-1, Tegafur/gimeracil/oteracil; TNBC, triple negative breast cancer


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Disclaimer

This article is not medical advice. Patients should seek personal assessment by a licenced specialist. Physicians are recommended to read the full publication(s) as cited in the article before making medical decisions. This article does not supersede nor replace the published article(s).

© Copyright 2021 MediPaper Medical Communications Ltd. – Breast cancer update January 2021

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Gastric Cancer ramucirumab cyramza pembrolizumab keytruda trastuzumab herceptin dMMR MSI HER2 VEGF VEGFR gastric adenocarcinoma GEJ gastroesophageal junction cancer
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Second-line treatment of gastric cancer or cancer of the gastroesophegeal junction: a case study of ramucirumab in Hong Kong

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Capivasertib added to fulvestrant improves progression-free survival in advanced breast cancer patients
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Capivasertib added to fulvestrant improves progression-free survival in advanced breast cancer patients

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Capivasertib combined with paclitaxel improves survival of metastatic triple-negative breast cancer patients
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Capivasertib plus paclitaxel improves survival of metastatic triple-negative breast cancer patients

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Olaparib plus Bevacizumab as Maintenance Therapy in Ovarian Cancer
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Olaparib plus Bevacizumab as Maintenance Therapy in Ovarian Cancer

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ADDING RIBOCICLIB TO FULVESTRANT IMPROVES THE SURVIVAL OF ADVANCED BREAST CANCER PATIENTS MONALEESA-3
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Ribociclib plus Fulvestrant Improves Survival in Advanced Breast Cancer

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ASCO 2019 lung cancer NSCLC ASCO19 SCLC mesothelioma KEYNOTE-189 KEYNOTE-001 IMpower150 MYSTIC LCMC3 Lung-MAP S1400G S1400I Flaura CALGB 30901 DETERRED COMPASS
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ASCO 2019 Lung Cancer: 36 Oral Presentations of the ASCO19 lung cancer track summarised

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paclitaxel, cobimetinib, Cotellic, MEK, Exelixis, atezolizumab, Tecentriq, nab-paclitaxel pembrolizumab, Keytruda, Merck, MSD, eribulin mesylate, Halaven, pertuzumab, trastuzumab, Herceptin, Perjeta, docetaxel, Taxotere, Sanofi, trastuzumab-dkst, Ogivri, Mylan, Biocon, margetuximab, MacroGenics, capecitabine, Xeloda, Genentech, gemcitabine, Gemzar, vinolrebine, pyrotinib, Jiangsu HengRui Medicine, neratinib, Nerlynx, Puma, lapatinib, Tykerb, carboplatin, T-DM1, ado-trastuzumab emtansine, Kadcyla doxorubicin, cisplatin, olaparib, Lynparza, cyclophosphamide, epirubicin, Ellence, Pharmorubicin, letrozole, Femara, Novartis, AI, NSAI, capivasertib, capivasertib, AZD5363, AKT, hormonal therapy, endocrine therapy, CDK4/6, RAD001, mTOR, fulvestrant, Faslodex, abemaciclib, Verzenio, Eli Lilly, ribociclib, Kisqali, goserilin, Zoladex, AstraZeneca, everolimus, Afinitor, exemestane, Aromasin, Pfizer, palbociclib, Ibrance, #ASCO2019, AKT1, AZ, BRCA, chemotherapy, CNS metastases, ER-positive, ESR1, GnRH, HER2-negative, HER2-positive, HR-positive, LABC, neoadjuvant, OfS, PARP, PARPi, pCR, PD-L1, postmenopausal, PR-positive, premenopausal, RB1, TAC, taxane, TNBC, trastuzumab, triptorelin
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ASCO 2019 Breast Cancer: The ASCO19 breast cancer track summarised

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Venetoclax FDA approved for CLL and SLL

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FDA approves avelumab plus axitinib for renal cell carcinoma

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Ramucirumab FDA approved for hepatocellular carcinoma

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T-DM1 FDA approved for early breast cancer

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Ivosidenib FDA-approved as first-line treatment for AML patients with IDH1 mutation

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Can a novel, temporary, and fully resorbable surgical implant improve the outcome of common hockey and soccer injuries?
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Can a novel, temporary, and fully resorbable surgical implant improve the outcome of common hockey and soccer injuries?

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Pembrolizumab plus axitinib FDA approved for the first-line treatment of advanced renal cell carcinoma patients

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KEYNOTE-158 pembrolizumab in previously treated advanced cervical cancer
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KEYNOTE-158: pembrolizumab in previously treated advanced cervical cancer

https://medi-paper.com/wp-content/uploads/2019/04/KEYNOTE-158-pembrolizumab-in-previously-treated-advanced-cervical-cancer.jpg 844 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-04-24 18:22:142019-04-24 18:22:14KEYNOTE-158: pembrolizumab in previously treated advanced cervical cancer
Atezolizumab with or without cobimetinib vs regorafenib for previously treated metastatic colorectal cancer IMblaze370
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Atezolizumab +/- cobimetinib vs regorafenib for previously treated metastatic colorectal cancer (IMblaze370)

https://medi-paper.com/wp-content/uploads/2019/04/Atezolizumab-with-or-without-cobimetinib-vs-regorafenib-for-previously-treated-metastatic-colorectal-cancer-IMblaze370.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-04-22 21:21:372019-04-22 21:57:04Atezolizumab +/- cobimetinib vs regorafenib for previously treated metastatic colorectal cancer (IMblaze370)
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Palbociclib approved for the treatment of male breast cancer 

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Erdafitinib FDA approved for the treatment of metastatic urothelial carcinoma

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Atezolizumab FDA approved for extensive-stage small cell lung cancer (SCLC)

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Atezolizumab FDA approved for PD-L1 positive unresectable triple-negative breast cancer

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Immunoncology I-O drugs and immunotherapy for renal cancer RCC
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Combinations: upcoming treatment strategies in metastatic renal cell carcinoma

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Trifluridine/tipiracil combination FDA approved for metastatic gastric or GEJ adenocarcinoma

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Pembrolizumab FDA approved for adjuvant treatment of melanoma

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Trastuzumab-biosimilar Ontruzant® FDA approved in several indications

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Cabozantinib FDA approved in HCC patients failing sorafenib

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Erasmus University MC investigating a new surgical matrix to reduce post-operative complications
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Erasmus University MC investigating a new surgical matrix to reduce post-operative complications

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Keytruda® FDA approved for recurrent and metastatic Merkel cell carcinoma

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Calaspargase pegol-mknl (Asparlas®) FDA approved in paediatric and young adult acute lymphoblastic leukaemia (ALL) patients

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Elzonris™ FDA approved for blastic plasmacytoid dendritic cell neoplasm (BPDCN)

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Olaparib (Lynparza) FDA approved as maintenance for BRCAm ovarian cancer

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Trastuzumab-biosimilar Herzuma® FDA approved in HER2+ breast cancer

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Frontline atezolizumab plus bevacizumab and chemotherapy FDA approved for metastatic non-squamous NSCLC

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MURANO: off-drug progression-free survival after 2 years venetoclax plus 6 cycles Rituximab
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MURANO: off-drug progression-free survival after 2 years venetoclax plus 6 cycles Rituximab

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TIGR®Matrix shows promising results when used for incisional hernia prevention in septic patients undergoing laparoscopy
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TIGR®Matrix shows promising results when used for incisional hernia prevention in septic patients undergoing laparoscopy

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Gilteritinib (Xospata®) FDA approved for relapsed or refractory AML harbouring FLT3 mutations

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TKR inhibitor larotrectinib (Vitrakvi®) FDA approved for cancers with NTRK gene fusion

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FDA Approves Truxima as Biosimilar to Rituxan

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Venetoclax plus azacitidine, decitabine, or low-dose cytarabine FDA approved in elderly AML patients

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Glasdegib plus low-dose cytarabine (LDAC) approved in elderly AML patients

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Robert Lewandowski Y90 TARE TheraSphere The Emerging Role of Yttrium90 in Primary and Metastatic Liver Cancer hepatocellular carcinoma hcc
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The Emerging Role of Yttrium-90 in Primary and Metastatic Liver Cancer

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Emapalumab FDA approved in adult and paediatric patients with primary hemophagocytic lymphohistiocytosis

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Brentuximab vedotin (Adcetris®) plus chemotherapy approved for several CD30 expressing lymphomas

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Fully resorbable synthetic matrix offers improved safety for breast cancer patients undergoing immediate breast reconstruction
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Fully resorbable synthetic matrix offers improved safety for breast cancer patients undergoing immediate breast reconstruction

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Pembrolizumab FDA approved in hepatocellular carcinoma patients pretreated with sorafenib

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Lorlatinib FDA approved for metastatic ALK-positive NSCLC

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ESMO 2018 HCC ESMO18 Liver Cancer ESMO2018 hepatocellular carcinoma hepatobiliary cholangiocarcinoma BTC
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ESMO 2018 HCC: The ESMO18 hepatobiliary cancer track summarised

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Pembrolizumab plus chemotherapy approved for metastatic squamous NSCLC

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Dr Joanne Chiu HKU management irAE hepatitis manage immune-mediated hepatitis immunotherapy I-O immunooncology immune-induced hepatitis
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Management of Immune-Mediated Hepatitis: a Case Report

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PARPi talazoparib FDA approved for deleterious gBRCAm HER2‑negative breast cancer

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innovent biologics anti-pd1 sintilimab plus biosimilar bevacizumab receive ind status by china nmpa
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Anti-PD1 sintilimab plus biosimilar bevacizumab receive IND-status by China NMPA

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IMpower133 first-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer
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IMpower133: first-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer

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Pembrolizumab plus chemotherapy effective in squamous NSCLC
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Pembrolizumab plus chemotherapy effective in squamous NSCLC

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Ipilimumab plus nivolumab for persistent or recurrent ovarian cancer
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Ipilimumab plus nivolumab for persistent or recurrent ovarian cancer

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Brigatinib prolongs PFS compared to crizotinib in ALK-Positive NSCLC
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Brigatinib prolongs PFS compared to crizotinib in ALK-Positive NSCLC

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CAR-T axicabtagene ciloleucel granted Orphan Drug Designation for B-Cell Lymphoma by the Japan MHLW
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CAR-T axicabtagene ciloleucel granted Orphan Drug designation for B-Cell Lymphoma by the Japan MHLW

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PD-1 mAB cemiplimab FDA approved for locally advanced and metastatic cutaneous squamous cell carcinoma (CSCC)

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JAVELIN Lung 200 avelumab vs docetaxel in patients with pretreated advanced non-small cell lung cancer NSCLC
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JAVELIN Lung 200: avelumab vs docetaxel for pretreated NSCLC

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Dacomitinib FDA approved for the first-line treatment of metastatic EGFR-mutated NSCLC

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MediPr medipr.org medi-paper.com MediNews Asia MediNews.asia MediNews.cn MediPaper Medical Communications Ltd Healthcare Writers Medical Writers Medical Writer Agency Hong Kong Medical Writing Services Solutions Quote 醫學寫作 香港 醫學作家香港
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©United States Food and Drug Agency US FDA

Duvelisib FDA approved for adult patients with R/R CLL or SLL

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MediPr medipr.org medi-paper.com MediNews Asia MediNews.asia MediNews.cn MediPaper Medical Communications Ltd Healthcare Writers Medical Writers Medical Writer Agency Hong Kong Medical Writing Services Solutions Quote 醫學寫作 香港 醫學作家香港
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©United States Food and Drug Agency US FDA

Duvelisib FDA approved for adult patients with R/R follicular lymphoma

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Front-line atezolizumab plus chemotherapy improves PFS in NSCLC
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Frontline atezolizumab plus chemotherapy improves PFS in NSCLC

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First-line osimertinib vs EGFR-TKI in Asian patients with advanced NSCLC
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First-line osimertinib vs EGFR-TKI in Asian patients with advanced NSCLC

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Early breast cancer treatment in China remains conservative
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Early breast cancer treatment in China remains conservative

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immuno-oncology I-O treatment for the irAE Rash
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ImmunoOncology: Dr Oscar Chan on the treatment of irAE rash

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Prof Stefan Kasper on I-O in EXTREME-ineligible Head and Neck Cancer I-O in SCCHN with focus on EXTREME-ineligible Patients and the future directions of combination immunotherapy
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Prof Stefan Kasper on I-O in EXTREME-ineligible SCCHN

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Camrelizumab anti-PD-1 with or without Chemotherapy for NPC
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Camrelizumab anti-PD-1 with or without chemotherapy for NPC

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Moxetumomab pasudotox-tdfk FDA approved for hairy cell leukaemia

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Adrian TSE HKIOC irAE pneumonitis lung immunotherapy-induced pneumonitis I-O Immuno-Oncology cannonball metastases cancer
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I-O in Special Populations: the Treatment of Immunotherapy-Induced Pneumonitis

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Venetoclax FDA label updated to include Minimal Residual Disease negativity data

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Quizartinib Receives Orphan Drug Designation for FLT3-Mutated AML in Japan
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Quizartinib receives Orphan Drug designation for FLT3-mutated AML in Japan

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Lung Cancer Capmatinib plus gefitinib promising in MET-dysregulated NSCLC MediPaper Medical Communications Medical Writer Hong Kong 醫學寫作 醫學作家香港
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Capmatinib plus gefitinib promising in MET-dysregulated NSCLC

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CAR-TCR Summit 2018 Preliminary first-in-human data with CAR-Claudin18.2-T in gastric and pancreatic cancer
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CAR-TCR Summit 2018: Preliminary first-in-human data with CAR-Claudin18.2-T in gastric and pancreatic cancer

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DRIVER connects cancer patients in China and the United States to the best care
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DRIVER connects cancer patients in China and the United States to the best care

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Blood-based TMB-assay predicts response to atezolizumab in NSCLC patients
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Plasma TMB predicts response to atezolizumab in NSCLC patients

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First-in-Class Oncology Vaccine BIL06v Starts Phase 1 Evaluation
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First-in-Class Oncology Vaccine BIL06v Starts Phase 1 Evaluation

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Nivolumab FDA approved for patients with metastatic small cell lung cancer (SCLC)
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Pembrolizumab and atezolizumab USPIs updated by FDA

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Nivolumab FDA approved for patients with metastatic small cell lung cancer (SCLC)
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Nivolumab FDA approved for patients with metastatic small cell lung cancer (SCLC)

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Pembrolizumab plus pemetrexed-platinum approved for use in the 1st-line treatment of metastatic non-squamous NSCLC
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Pembrolizumab plus pemetrexed-platinum FDA approved for first-line treatment of metastatic non-squamous NSCLC

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Talazoparib in advanced breast cancer patients with a germline BRCA1:2 mutation
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Talazoparib in advanced breast cancer patients with a germline BRCA1/2 mutation

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CheckMate 032 Nivolumab ipilimumab metastatic esophagogastric cancer
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CheckMate 032: Nivolumab +/- ipilimumab for metastatic esophagogastric cancer

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Pembrolizumab plus pemetrexed-platinum approved for use in the 1st-line treatment of metastatic non-squamous NSCLC
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Lenvatinib FDA approved for 1st-line treatment of HCC

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Pan-EGFR TKI pirotinib has commenced into Phase II clinical testing in China
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Pan-EGFR TKI pirotinib has commenced into Phase II clinical testing in China

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FDA approved lusutrombopag (Mulpleta, Shionogi Inc.) for thrombocytopenia in adults with chronic liver disease who are scheduled to undergo a medical or dental procedure. More Information.  July 31, 2018.
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FDA approved mogamulizumab for adult patients with relapsed or refractory CTCL

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FDA approved lusutrombopag (Mulpleta, Shionogi Inc.) for thrombocytopenia in adults with chronic liver disease who are scheduled to undergo a medical or dental procedure. More Information.  July 31, 2018.
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Lusutrombopag FDA approved for thrombocytopenia in adult chronic liver disease patients

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Ribociclib FDA label updated to include pre- and perimenopausal women
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Iobenguane I-131 FDA approved for rare adrenal neuroendocrine tumours

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T790M osimertinib nsclc brain metastasis CNS metastases Osimertinib in patients With T790M-Positive Advanced Non-Small-Cell Lung Cancer and brain metastases AURA3
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Osimertinib in patients with T790M-positive advanced non-small cell lung cancer and brain metastases (AURA3)

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Anti-PD1 with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma
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Anti-PD1 with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma

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Ribociclib FDA label updated to include pre- and perimenopausal women
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Ivosidenib FDA approved for relapsed or refractory acute myeloid leukemia

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FDA approved enzalutamide (XTANDI, Astellas Pharma US, Inc.), for patients with castration-resistant prostate cancer (CRPC). More Information.  July 13, 2018
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Filgrastim-aafi FDA approved as Filgrastim Biosimilar

https://medi-paper.com/wp-content/uploads/2018/07/FDA-approved-enzalutamide-XTANDI-Astellas-Pharma-US-Inc.-for-patients-with-castration-resistant-prostate-cancer-CRPC.-More-Information-.-July-13-2018-e1537925607982.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-20 10:58:232018-08-11 23:55:01Filgrastim-aafi FDA approved as Filgrastim Biosimilar
Ribociclib FDA label updated to include pre- and perimenopausal women
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Ribociclib FDA label updated to include pre- and perimenopausal women

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FDA approved enzalutamide (XTANDI, Astellas Pharma US, Inc.), for patients with castration-resistant prostate cancer (CRPC). More Information.  July 13, 2018
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Enzalutamide FDA approved for castration-resistant prostate cancer (CRPC)

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EBV pembrolizumab gastric cancer - MSI-H pembrolizumab gastric cancer - CPS pembrolizumab gastric cancer - MSI, EBV, CPS predict pembrolizumab outcome in gastric cancer
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EBV, MSI, and CPS predict pembrolizumab outcome in gastric cancer

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Ribociclib FDA label updated to include pre- and perimenopausal women
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Ipilimumab plus nivolumab FDA approved for MSI-H and dMMR pre-treated mCRC

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Ribociclib FDA label updated to include pre- and perimenopausal women
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Combination encorafenib plus binimetinib for unresectable/metastatic BRAF V600E or V600K-positive melanoma FDA approved

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ASCO 2018 nsclc immunotherapy ASCO18 lung cancer pembrolizumab avelumab nivolumab duravalumab ipilimumab osimertinib dacomitinib lorlatinib crizotinib alectinib keytruda KEYNOTE CheckMate JAVELIN IMpower
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ASCO 2018 NSCLC: The ASCO18 Lung Cancer Track Summarised

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FDA  has limited the use of Tecentriq and Keytruda for patients with locally advanced or metastatic urothelial cancer who are not eligible for cisplatin-containing therapy.  More Information.  June 19, 2018
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FDA limits use of atezolizumab and pembrolizumab in urothelial carcinoma

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ASCO 2018 breast cancer TNBC MBC ABC ASCO18 PHEREXA D-CARE ABCSG-18 ASTRRA TEXT SOFT MONARCH-2 MONALEESA-3 SANDPIPER BOLERO-6 TOPACIO KEYNOTE-162 TONIC TOPACIO GeparNeuvo
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ASCO 2018 Breast Cancer: The ASCO18 breast cancer track summarised

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Ribociclib FDA label updated to include pre- and perimenopausal women
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Bevacizumab in combination with carboplatin and paclitaxel FDA approved for several types of gynaecological cancers

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Ribociclib FDA label updated to include pre- and perimenopausal women
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FDA approved pembrolizumab for 3rd-line PMBCL in adult and pediatric patients

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Ribociclib FDA label updated to include pre- and perimenopausal women
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FDA approved pembrolizumab for chemotherapy-refractory r/m cervical cancer with PD-L1 CPS ≥1 

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ASCO18 ASCO 2018 HCC hepatocellular carcinoma liver cancer pembrolizumab KEYTRUDA atezolizumab TECENTRIQ PD-1 PD-L1 immunecheckpoint immunotherapy ramucirumab cabozantinib KEYNOTE-224 SCRUM-Japan GI-SCREEN CELESTIAL REACH-2
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ASCO 2018 HCC: The ASCO18 hepatocellular cancer track summarised

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Ribociclib FDA label updated to include pre- and perimenopausal women
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FDA approves venetoclax in 2nd-line for patients with CLL or SLL

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Ribociclib FDA label updated to include pre- and perimenopausal women
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FDA approved biosimilar pegfilgrastim to decrease the chance of febrile neutropenia in patients with non-myeloid cancers on myelosuppressive chemotherapy

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IMPower150 Reck Socinski ELCC AACR 2018 firstline atezolizumab bevacizumab chemotherapy non-squamous nsclc
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AACR 2018: first-line atezolizumab, bevacizumab plus chemotherapy active in non-squamous NSCLC

https://medi-paper.com/wp-content/uploads/2018/05/IMPower150-Reck-Socinski-ELCC-AACR-2018-firstline-atezolizumab-bevacizumab-chemotherapy-non-squamous-nsclc.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-05-10 16:19:462018-05-24 09:31:31AACR 2018: first-line atezolizumab, bevacizumab plus chemotherapy active in non-squamous NSCLC
US FDA approved CAR-t cell BiTE DAR-T cell CD19 Immunotherapies blinatumomab axicabtagene ciloleucel tisagenlecleucel
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US FDA approved CAR-T cell and BiTE immunotherapy – Updated 2-May-2018

https://medi-paper.com/wp-content/uploads/2018/04/US-FDA-approved-CAR-t-cell-BiTE-DAR-T-cell-CD19-Immunotherapies-blinatumomab-axicabtagene-ciloleucel-tisagenlecleucel.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-05-02 10:00:352018-05-24 09:36:21US FDA approved CAR-T cell and BiTE immunotherapy – Updated 2-May-2018
Ribociclib FDA label updated to include pre- and perimenopausal women
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Adjuvant dabrafenib plus trametinib FDA approved for BRAF V600E or V600K melanoma

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AACR 2018 First-line Nivolumab-Ipilimumab in TMB-high NSCLC front-line immunotherapy for non-small cell lung cancer tumour-mutation burden CheckMate 227 NCT02477826
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Nivolumab-Ipilimumab Combination: A New Option for TMB-High NSCLC (CheckMate 227)

https://medi-paper.com/wp-content/uploads/2018/04/First-line-Nivolumab-Ipilimumab-in-TMB-high-NSCLC-front-line-immunotherapy-for-non-small-cell-lung-cancer-CheckMate-227-NCT02477826.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-04-21 10:30:432018-05-24 09:37:03Nivolumab-Ipilimumab Combination: A New Option for TMB-High NSCLC (CheckMate 227)
Ribociclib FDA label updated to include pre- and perimenopausal women
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FDA approved osimertinib for the 1st-line treatment of patients with EGFR exon 19 deletions or exon 21 L858R mutations positive metastatic non-small cell lung cancer (NSCLC)

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NCT02578680 Keynote189 AACR 2018 pembrolizumab chemotherapy nsclc NEJM Leena Gandhi
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Frontline Combination of Pembrolizumab and Chemotherapy: A New Standard of Care for Non-squamous NSCLC

https://medi-paper.com/wp-content/uploads/2018/04/NCT02578680-Keynote189-pembrolizumab-chemotherapy-nsclc-NEJM-Leena-Gandhi.jpg 938 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-04-19 01:27:262018-05-24 09:37:16Frontline Combination of Pembrolizumab and Chemotherapy: A New Standard of Care for Non-squamous NSCLC
Ribociclib FDA label updated to include pre- and perimenopausal women
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Frontline nivolumab plus ipilimumab approved for intermediate or poor risk advanced RCC

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Keynote-042 Keynote-024 pembrolizumab nsclc keytruda nsclc non-squamous squamous PD-L1 expression 1% 20% 50% Tony Mok MD NCT02220894 Pembrolizumab effective in frontline NSCLC with low PD-L1 expression
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Pembrolizumab effective in frontline NSCLC with low PD-L1 expression

https://medi-paper.com/wp-content/uploads/2018/04/Keynote-042-Keynote-024-pembrolizumab-nsclc-keytruda-nsclc-non-squamous-squamous-PD-L1-expression-1-20-50-Tony-Mok-MD-NCT02220894-Pembrolizumab-effective-in-frontline-NSCLC-with-low-PD-L1-expression.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-04-10 20:15:112018-05-24 09:37:32Pembrolizumab effective in frontline NSCLC with low PD-L1 expression
Ribociclib FDA label updated to include pre- and perimenopausal women
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Everolimus suspension approved in TSC-associated partial-onset seizures

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Herbert Loong on irAEs Immunotherapy (I-O) and New Onset Diabetes or immune-mediated diabetes